Predictive Value of Collagen Biomarkers for Heart Failure With and Without Preserved Ejection Fraction: MESA (Multi-Ethnic Study of Atherosclerosis)

Journal of the American Heart Association
Daniel A DuprezDavid R Jacobs

Abstract

Collagen biomarkers may correlate with incident heart failure (HF) and its subtypes. We hypothesized that circulating procollagen type III N-terminal propeptide (PIIINP) and collagen type I carboxy-terminal telopeptide (ICTP) predict incident HF. We used a stratified sampling design in a multiethnic sample of 3187 subjects, initially aged 45 to 84 years and free of cardiovascular disease. We assayed baseline serum PIIINP and ICTP concentrations using radioimmunoassay. Incident HF was adjudicated, distinguishing reduced ejection fraction (HFrEF; EF <45%) from preserved EF (HFpEF; EF ≥45%). The incidence density for HFpEF and HFrEF was computed using Poisson regression per SD for each of PIIINP and ICTP, adjusting in model 1 for age, race, sex, and renal function or in model 2 for these variables plus blood pressure and medication. Mean (SD) ICTP was 3.38±1.77 μg/L, and mean (SD) PIIINP was 5.48±2.04 μg/L. Among the HF cases, 96 were HFrEF and 107 were HFpEF. Neither ICTP nor PIIINP significantly predicted incident HFrEF. The incidence density for HFpEF per 100 people observed for 13 years was 1.65 for low PIIINP (lower 6 octiles) versus 3.00 for higher PIIINP (P=0.002) in model 1 and correspondingly 1.45 versus 2.59 (P=0.003) in...Continue Reading

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Citations

Apr 26, 2019·Journal of the American Heart Association·Thomas A ZelnikerDavid A Morrow
Nov 22, 2019·Trauma Surgery & Acute Care Open·James ButzThai Vu
Apr 29, 2020·BMJ Open Sport & Exercise Medicine·Kelsley E JoyceArthur Bradwell
Jun 12, 2020·Alimentary Pharmacology & Therapeutics·Signe WieseFlemming Bendtsen
Oct 30, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Joshua D BundyUNKNOWN CRIC Study Investigators
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Brian T SteffenMichael Y Tsai
Oct 10, 2018·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Muneyoshi Okada
Sep 12, 2018·G3 : Genes - Genomes - Genetics·Liang-Yu LinAdriana Huertas-Vazquez
May 21, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Alexander E Berezin, Alexander A Berezin
Oct 28, 2020·Circulation Research·Ana Rubina PerestreloGiancarlo Forte
Jan 20, 2021·Clinical and Translational Medicine·Tianlin HeVera Jankowski
Nov 27, 2020·Journal of Hypertension·Lyndia C BrumbackMatthew A Allison
Apr 22, 2021·Current Hypertension Reports·R Brandon Stacey, W Gregory Hundley

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Methods Mentioned

BETA
ELISA
glycosylation
nuclear magnetic resonance
biopsy

Software Mentioned

LipoProfile
SAS
MESA

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