Predictive value of computed tomography scoring systems evolution in adults with cystic fibrosis

European Radiology
Cristina ZorzoRosa M Girón

Abstract

To assess whether the evolution of two consecutive high-resolution computed tomography (HRCT) scores in patients with cystic fibrosis (CF) has prognostic value. A longitudinal retrospective study was performed to research adult patients with CF. Two consecutive HRCT studies were scored using Bhalla and Brody II scoring scales by two senior radiologists. Annual scoring changes for each scale were calculated and correlated with annual FEV1% decline, with pulmonary exacerbations and number of antibiotic treatments. We selected sixty-four adult patients. The median interval between the two HRCTs was 3.88 ± 1.59 years. The mean spirometric values showed dynamic lung volumes lower than the general population; globally, there was a worsening of respiratory function over time. The change in the annual HRCT scores was positive on both scales, indicating a worse structural situation over time. The Brody II scale annual change showed a significant statistical correlation with a decline in the annual FEV1%, exacerbations and number of oral antibiotic treatments. In contrast, for the Bhalla scale, the relationship was moderately inverse with exacerbations and with the number of oral treatments. No statistically significant relationships wer...Continue Reading

References

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Citations

Jan 15, 2021·Archivos de bronconeumología·Layla Diab CáceresPaloma Caballero Sánchez-Robles
Sep 6, 2021·Current Opinion in Pulmonary Medicine·Claire CrowleyMichael M Maher

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