PMID: 9556920Apr 29, 1998Paper

Predictive value of creatine kinase (CK)-MB for diagnosis of acute myocardial infarction after major noncardiac surgery

Archives of Medical Research
F López-JiménezT H Lee

Abstract

The aim of this study was to provide insight into the interpretation of CK-MB data after major noncardiac surgery. Some 3,321 patients who underwent major non-emergent noncardiac procedures (orthopedic 31%, intrathoracic 12%, vascular 22%, other 35%) were studied. All patients had at least two CK samples measured postoperatively. Acute myocardial infarction was diagnosed in 43 (1.3%) patients using study criteria including CK-MB and electrocardiographic data. All of the various threshold values of peak CK-MB values and peak CK-MB as a percentage of total CK had poor positive predictive values because of high false positive rates and the low rate of acute myocardial infarction. These data demonstrate the need for markers of myocardial injury with greater cardiac specificity after noncardiac surgery.

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