Iron deficiency anemia (IDA) and beta-thalassemia trait (B-TT) are the most common causes of hypochromic microcytic anemias. Many indices have been defined to quickly discriminate these similar entities via parameters obtained from automated blood count analyzers. The purpose of the study was to evaluate the predictive value of these indices in differential diagnosis of IDA and B-TT in adult cases. This study consists of 45 IDA cases, 36 women and nine men, whose mean age is 33.87 +/- 11.59 (mean +/- SD) (range 17-57 yr) and 66 B-TT cases, 41 women and 25 men, whose mean age is 33.26 +/- 13.36 (mean +/- SD) (range 14-74 yr). IDA cases with Hb value <8.7 g/dL have been excluded because these cases are not confused with B-TT cases in practice. Patient groups have been evaluated according to red blood cell (RBC), red blood cell distribution width (RDW), Mentzer index, Shine and Lal indices, England and Fraser indices, Srivastava index, Green and King indices, RDW index and Ricerca index. Sensitivity, specificity, positive and negative predictive values and Youden's index have been calculated. Finally, none of these different formulations are superior to RBC value obtained from automated analyzers in adult cases with IDA and B-TT. ...Continue Reading
The evaluation of various mathematical RBC indices and their efficacy in discriminating between thalassemic and non-thalassemic microcytosis
Discriminant value of % microcytic/% hypochromic ratio in the differential diagnosis of microcytic anemia
Potential utility of the new Sysmex XE 5000 red blood cell extended parameters in the study of disorders of iron metabolism
A new index for discrimination between iron deficiency anemia and beta-thalassemia minor: results in 284 patients
Red blood cell flags for the differential diagnosis between thalassemia trait and iron deficiency anemia
A local equation for differential diagnosis of β-thalassemia trait and iron deficiency anemia by logistic regression analysis in Southeast Iran
Red Cell Indices and Formulas Used in Differentiation of β-Thalassemia Trait from Iron Deficiency in Thai Adults
Incorporation of erythrocytic and reticulocytic parameters in a common formula: will it provide a more accurate differentiation between iron deficiency anemia and beta-thalassemic trait?
Red blood cell microcytosis and hypochromia in the differential diagnosis of iron deficiency and beta-thalassaemia trait
Discrimination indices have no predictive value in differential diagnosis of iron deficiency anemia and beta-thalassemia trait
Beta-thalassemic trait cannot be safely differentiated from iron deficiency anemia by red blood cell indices
The role of automated measurement of red cell subpopulations on the Sysmex XE 5000 analyzer in the differential diagnosis of microcytic anemia
RBC-Y/MCV as a discriminant function for differentiating carriers of thalassaemia and HbE from iron deficiency
Proposal of a score combining red blood cell indices for early differentiation of beta-thalassemia minor from iron deficiency anemia
Comparison of discriminative indices for iron deficiency anemia and β thalassemia trait in a Brazilian population
Discriminant indices for distinguishing thalassemia and iron deficiency in patients with microcytic anemia: a meta-analysis
Indices used in differentiation of thalassemia trait from iron deficiency anemia in pediatric population: are they reliable?
Evaluation of Applying a Combination of Red Cell Indexes and Formulas to Differentiate β-Thalassemia Trait from Iron Deficiency Anemia in the Thai Population
Red cell indices and functions differentiating patients with the beta-thalassaemia trait from those with iron deficiency anaemia
The role of automated measurement of RBC subpopulations in differential diagnosis of microcytic anemia and β-thalassemia screening
Proxy indicators for identifying iron deficiency among anemic vegetarians in an area prevalent for thalassemia and hemoglobinopathies
Evaluation of indices in differentiation between iron deficiency anemia and beta-thalassemia trait for Chinese children
The role of discriminant functions in screening beta thalassemia trait and iron deficiency anemia among laboratory samples
Diagnostic performance of hematological discrimination indices to discriminate between βeta thalassemia trait and iron deficiency anemia and using cluster analysis: Introducing two new indices tested in Iranian population
The value of the red cell distribution width index versus other parameters in the differentiation between iron deficiency anemia and beta thalassemia trait among children in Mosul, Iraq.
Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.