Predictive value of early magnetic resonance imaging measures is differentially affected by the dose of interferon beta-1a given subcutaneously three times a week: an exploratory analysis of the PRISMS study

BMC Neurology
A TraboulseeAaron Miller

Abstract

On-treatment magnetic resonance imaging lesions may predict long-term clinical outcomes in patients receiving interferon β-1a. This study aimed to assess the effect of active T2 and T1 gadolinium-enhancing (Gd+) lesions on relapses and 3-month confirmed Expanded Disability Status Scale (EDSS) progression in the PRISMS clinical trial. Exploratory analyses assessed whether active T2 and T1 Gd + lesions at Month 6, or active T2 lesions at Month 12, predicted clinical outcomes over 4 years in PRISMS. Mean active T2 lesion number at Month 6 was significantly lower with interferon beta-1a given subcutaneously (IFN β-1a SC) 44 μg and 22 μg 3×/week (tiw) than with placebo (p < 0.0001). The presence of ≥4 versus 0 active T2 lesions predicted disability progression at Years 3-4 in the IFN β-1a SC 22 μg group only (p < 0.05), whereas the presence of ≥2 versus 0-1 active T2 lesions predicted disability progression in the placebo/delayed treatment (DTx) (Years 2-4; p < 0.05) and IFN β-1a SC 22 μg groups (Years 3-4; p < 0.05). Greater active T2 lesion number at 6 months predicted relapses in the placebo/DTx group only (≥4 vs. 0, Years 1-4; ≥2 vs. 0-1, Years 2-4; p < 0.05), and the presence of T1 Gd + lesions at 6 months predicted disability ...Continue Reading

References

Jun 27, 2001·Neurology·UNKNOWN PRISMS Study Group and the University of British Columbia MS/MRI Analysis Group.
Sep 25, 2004·Annals of Neurology·Richard A RudickElizabeth Fisher
Nov 8, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·L DurelliUNKNOWN Italian Multiple Sclerosis Study Group
Jun 20, 2008·Multiple Sclerosis : Clinical and Laboratory Research·J RíoX Montalban
Jun 23, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L ProsperiniC Pozzilli
Oct 2, 2009·Nature Reviews. Neurology·Jordi RíoXavier Montalban
Jan 22, 2010·The New England Journal of Medicine·Jeffrey A CohenUNKNOWN TRANSFORMS Study Group
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Jun 16, 2011·Current Medical Research and Opinion·Bernard M J UitdehaagDaniel D Mikol
Sep 21, 2012·The New England Journal of Medicine·Robert J FoxUNKNOWN CONFIRM Study Investigators
Sep 21, 2012·The New England Journal of Medicine·Ralf GoldUNKNOWN DEFINE Study Investigators
Sep 27, 2012·Multiple Sclerosis : Clinical and Laboratory Research·M P SormaniN De Stefano
Feb 5, 2013·Annals of Neurology·Robert A BermelRichard A Rudick
Dec 18, 2013·Neurology·Ruth DobsonGavin Giovannoni
Jul 22, 2015·Multiple Sclerosis and Related Disorders·Gavin GiovannoniMonica Marta

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