Predictive Value of FDG PET/CT to Detect Lymph Node Metastases in Cervical Cancer

Clinical Nuclear Medicine
Laurie L BrunetteLynda D Roman

Abstract

The aim of this study was to determine the prognostic significance of PET/CT findings in women with cervical cancer and describe the normalization of lymph node SUVmax (nSUVmax). A retrospective review was performed of 113 patients with cervical cancer who underwent a PET/CT before receiving definitive therapy. SUVmax measurements were normalized to the SUV of the pelvic blood pool. Patient, tumor, and PET/CT data were correlated to extracervical recurrence-free survival (ecRFS) and lymph node pathology. Of 113 patients, there were 23 (20%) extracervical recurrences. On univariate analysis, stage, histology, nSUVmax, and radiographic size of the primary tumor, and nSUVmax of the most hypermetabolic lymph node were significantly associated with ecRFS. On multivariable analysis, nSUVmax and radiographic size of the primary tumor remained associated with ecRFS (both P < 0.001). Sixty-six patients underwent pelvic, common iliac, and/or para-aortic nodal sampling. The sensitivity, specificity, false-negative, and false-positive rates of PET/CT for lymph node metastases were 53%, 75%, 6%, and 82%, respectively. On univariate analysis, nSUVmax, and radiographic size of the primary tumor, and nSUVmax of the most hypermetabolic lymph no...Continue Reading

References

Aug 22, 2000·European Journal of Nuclear Medicine·K D StumpeG K von Schulthess
Dec 13, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M A QuinnS Pecorelli
May 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mathias BoughanimPhilippe Morice
Dec 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L H SchwartzE A Eisenhauer
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Apr 4, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sergio PecorelliFranco Odicino
Dec 25, 2009·Nuclear Medicine Communications·Raef RiadHussein M Abdel-Dayem
May 25, 2010·International Journal of Radiation Oncology, Biology, Physics·Chrishanthi RajasooriyarKailash Narayan
Jun 23, 2010·Current Oncology·L ElitUNKNOWN members of the Gynecology Cancer Disease Site Group of Cancer Care Ontario’s Program in Evidence-Based Care
Jan 25, 2012·Annals of Nuclear Medicine·Norihisa ShironeMasatoshi Hasegawa
Nov 28, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Keiichiro NakamuraYuji Hiramatsu
Jul 18, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yu ZhangXiuwei Chen
Nov 1, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M A QuinnS Pecorelli

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Citations

Jun 18, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Youn Ji KimSeok Ho Lee
Jan 28, 2021·Scientific Reports·Kotaro ShimuraTadashi Kimura
Apr 12, 2021·BMC Pregnancy and Childbirth·Tatsuya IshiguroTakayuki Enomoto

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