Predictive value of fever and palmar pallor for P. falciparum parasitaemia in children from an endemic area.

PloS One
Christof David VinnemeierJürgen May

Abstract

Although the incidence of Plasmodium falciparum malaria in some parts of sub-Saharan Africa is reported to decline and other conditions, causing similar symptoms as clinical malaria are gaining in relevance, presumptive anti-malarial treatment is still common. This study traced for age-dependent signs and symptoms predictive for P. falciparum parasitaemia. In total, 5447 visits of 3641 patients between 2-60 months of age who attended an outpatient department (OPD) of a rural hospital in the Ashanti Region, Ghana, were analysed. All Children were examined by a paediatrician and a full blood count and thick smear were done. A Classification and Regression Tree (CART) model was used to generate a clinical decision tree to predict malarial parasitaemia a7nd predictive values of all symptoms were calculated. Malarial parasitaemia was detected in children between 2-12 months and between 12-60 months of age with a prevalence of 13.8% and 30.6%, respectively. The CART-model revealed age-dependent differences in the ability of the variables to predict parasitaemia. While palmar pallor was the most important symptom in children between 2-12 months, a report of fever and an elevated body temperature of ≥37.5°C gained in relevance in child...Continue Reading

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Citations

Sep 17, 2013·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Gabrielle A JacquetUNKNOWN Global Emergency Medicine Literature Review (GEMLR) Group
Oct 27, 2015·PeerJ·Antonio C MartinsMônica da Silva-Nunes
Sep 13, 2012·PloS One·Maja Verena NielsenNorbert Georg Schwarz
Nov 9, 2021·Frontiers in Cellular and Infection Microbiology·Mohamed OmarMohamed Tarek Badr

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Software Mentioned

IMCI
CART
STATA

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