PMID: 7527424Aug 1, 1994Paper

Predictive value of human chorionic gonadotrophin in the outcome of early pregnancy after in-vitro fertilization and spontaneous conception

Human Reproduction
F Zegers-HochschildP Orihuela

Abstract

This prospective study analyses the value of the beta-subunit of human chorionic gonadotrophin (beta-HCG) in 120 pregnancies obtained after in-vitro fertilization (IVF)--embryo transfer. Spontaneous conception cycles (n = 16) were also analysed allowing a comparison between these two forms of conception. Of the 120 clinical pregnancies, 48 started as single gestations and 50 started with two or more sacs. There were 14 clinical abortions and eight ectopic pregnancies. All subjects had blood samples taken under a fixed protocol on days 11, 14, 17, 20 and 23 after follicular aspiration. Weekly samples were obtained thereafter until day 60 from ovum retrieval. Transvaginal ultrasounds were performed at weekly intervals, starting on day 23 after follicular aspiration. In spontaneous conception cycles blood samples were obtained daily, starting on the day of follicular rupture. In spontaneous conception cycles and in IVF-embryo transfer conceptions, the doubling time (DT) of beta-HCG was 1.4 +/- 0.3 and 1.6 +/- 0.4 days respectively. This difference was not significant. In multigestations, the DT was 1.5 +/- 0.3 days. The absolute values of beta-HCG in early spontaneous gestations were significantly higher than in IVF-embryo transfe...Continue Reading

Citations

Mar 1, 1995·Journal of Assisted Reproduction and Genetics·F Zegers-Hochschild, E Altieri
Jul 8, 1998·The Australian & New Zealand Journal of Obstetrics & Gynaecology·N JohnsonG Gudex
Jul 3, 2004·Current Opinion in Obstetrics & Gynecology·Janine Elson, Davor Jurkovic
Jun 2, 2014·Journal of Assisted Reproduction and Genetics·Yamei XueSongying Zhang
Mar 2, 2006·Obstetrics and Gynecology·Celso SilvaKurt Barnhart
Sep 27, 2019·Journal of Immunoassay & Immunochemistry·Jackie BoxerSarah Johnson
Jul 2, 2004·Obstetrics and Gynecology·Kurt T BarnhartWensheng Guo
Apr 20, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Thushari Indika AlahakoonPeter Illingworth
Nov 29, 2005·Human Reproduction·Karine ChungKurt T Barnhart
Oct 5, 2010·Human Reproduction·G GiritharanP F Rinaudo
Nov 13, 2001·Fertility and Sterility·C A RichardJ A DeLoia

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