Predictive value of human leucocyte antigen epitope matching using HLAMatchmaker for graft outcomes in a predominantly African-American renal transplant cohort

Clinical Transplantation
Abdolreza HaririanSandra L Nehlsen-Cannarella

Abstract

The HLAMatchmaker program is based on the donor/recipient comparison of the polymorphic triplet amino-acid sequences of the antibody-accessible regions on the human leucocyte antigen (HLA) molecule. The previous reports on its predictive value for renal allograft outcomes are conflicting. We conducted a retrospective study in a predominantly African-American (AA) cohort (N = 101, 94% AA). HLA typing was performed by molecular methods and triplet matching using HLAMatchmaker. Study end points included graft survival and incidence of acute rejection. The relationship between the number of triplet mismatches (TMM) and the degree of HLA antigen MM was evaluated using Pearson's correlation coefficient. Logistic regression models were used to examine the association between triplet matching and the study end points. Kaplan-Meier and Cox proportional hazard models were used for graft survival analysis. The strongest relationship between the number of TMM and HLA antigen MM was observed for HLA-DQ (r = 0.88). The association between triplet matching at HLA-A, -B, -DR and -DRw HLA loci and the study end points was not statistically significant. However, after grouping, the unadjusted estimates of graft survival for those with more than ...Continue Reading

References

Jan 1, 1998·Transplantation Proceedings·A A ZacharyW B Bias
May 1, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S Sumitran-Holgersson
May 1, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gerhard Opelz
Aug 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Xuanming SuGlenn M Chertow

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Citations

May 29, 2014·Journal of Immunology Research·Kirsten GeneugelijkEric Spierings
Dec 19, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R Sapir-PichhadzeS J Kim
Jun 23, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C WiebeP W Nickerson
Jun 16, 2012·Transplant Immunology·Herton Luiz Alves Sales FilhoSemiramis Jamil Hadad do Monte
Sep 24, 2011·Transplant Immunology·Luiz Cláudio Demes da Mata SousaSemíramis Jamil Hadad do Monte
Jan 11, 2017·Journal of Immunology Research·Edward J Filippone, John L Farber
Aug 25, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Chandrashekhar A KubalAndrew Lobashevsky
May 7, 2009·Current Opinion in Organ Transplantation·René J Duquesnoy, Marilyn Marrari
Jul 1, 2016·Transplantation·Chris Wiebe, Peter Nickerson
Jul 1, 2014·Current Opinion in Organ Transplantation·Chris Wiebe, Peter Nickerson

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