PMID: 11917238Mar 28, 2002Paper

Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection

Journal of Acquired Immune Deficiency Syndromes : JAIDS
J V GiorgiMulticenter AIDS Cohort Study

Abstract

Laboratory markers that predict HIV-1 disease progression include plasma viral burden, CD4+ T-cell count, and CD38 expression on CD8 T cells. To better understand whether the predictive value of these markers is dependent on how long an individual has been infected, we analyzed data from the Multicenter AIDS Cohort Study early (median = 2.8 years) and late (median = 8.7 years) in the course of infection. Overall, we found that HIV RNA and CD38 levels were similarly predictive of AIDS early on compared with a relatively weaker CD4 cell count signal. Later in the course of infection, CD38 level remained the strongest predictive marker and CD4 cell count registered a marked increase in prognostic power. Among untreated individuals, there was little difference in prognosis (median time to AIDS) associated with given marker values regardless of infection duration. The prognosis given a specific viral load level tended to deteriorate late in the course of infection among those undergoing treatment with monotherapy or combination therapy, however. These data provide a unique historical look at the predictive value and prognostic significance of HIV-1 disease markers at different stages of infection in a large cohort, with direct relev...Continue Reading

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Citations

Aug 15, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Richard W PriceMagnus Gisslen
Oct 16, 2012·Nature Biotechnology·Xu TanStephen J Elledge
Jul 20, 2012·The New England Journal of Medicine·Joakim EsbjörnssonPatrik Medstrand
Apr 21, 2011·Blood·Jason M Brenchley, Mirko Paiardini
Apr 24, 2014·The Journal of Infectious Diseases·Peter W HuntMichael M Lederman
Sep 28, 2006·Blood·Ivona PandreaGuido Silvestri
Nov 3, 2007·The Journal of Clinical Investigation·Guido SilvestriDonald L Sodora
Aug 13, 2008·Clinical & Developmental Immunology·Yi JiangJonathan H Williams
Aug 15, 2009·The Journal of Infectious Diseases·Alison J RodgerUNKNOWN INSIGHT Strategies for Management of Antiretroviral Therapy (SMART) Study Group
Dec 5, 2009·The Journal of Clinical Investigation·Steven E BosingerDavid J Kelvin
Dec 17, 2009·Nature Reviews. Immunology·Andrew J McMichaelBarton F Haynes
Apr 29, 2010·Current HIV/AIDS Reports·Seema Desai, Alan Landay
Oct 12, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Enrique EspinosaMichael M Lederman
Jun 1, 2011·PloS One·Vincent C MarconiUNKNOWN Infectious Disease Clinical Research Program (IDCRP) HIV Working Group
Oct 7, 2011·The American Journal of Tropical Medicine and Hygiene·Denise NanichePedro Alonso
Jan 10, 2012·Annual Review of Immunology·Jason M Brenchley, Daniel C Douek
Mar 2, 2013·Journal of Translational Medicine·Lidia GazzolaGiulia Marchetti

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