Predictive value of inflammatory indexes on the chemotherapeutic response in patients with unresectable lung cancer: A retrospective study

Oncology Letters
Haifeng SunXinying Wang

Abstract

Chemotherapy is widely administered to patients with advanced lung cancer; however, data regarding chemotherapeutic sensitivity are limited. The present study aimed to investigate the predictive value of inflammatory indexes for chemotherapeutic efficacy in advanced lung cancer. Patients with stage III and IV unresectable lung cancer that were treated with first-line chemotherapy between January 2007 and December 2011 were retrospectively identified, and chemotherapeutic response was evaluated following 2 or 3 chemotherapy cycles. Prior to chemotherapy, hematologic data and clinicopathological parameters were collected using electronic medical records. The associations between the main inflammatory indexes [which included the pretreatment neutrophil count (PNC), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR)] and the chemotherapeutic efficacy, as well as the prognostic value of the indexes, were analyzed. According to the receiver operating characteristic curve, PLR failed to reach diagnostic accuracy for overall chemotherapeutic response. PNC and NLR were each classified into two groups according to the cut-off values (4.635×109/l for PNC and 2.443 ×109/l for NLR). The overall response rate was significantl...Continue Reading

References

Dec 3, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E RaymondE Cvitkovic
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Apr 2, 2005·Nature Reviews. Cancer·Chikashi Nakanishi, Masakazu Toi
Nov 14, 2007·Cell Cycle·Piet BorstSven Rottenberg
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jan 1, 2009·Journal of the National Cancer Institute·Vicki Brower
Jun 13, 2009·Current Pharmaceutical Design·Karin E de Visser, Jos Jonkers
Sep 11, 2009·Journal of Leukocyte Biology·G SolinasP Allavena
Oct 29, 2009·Biochemical and Biophysical Research Communications·Hiromitsu HoshinoHideshi Ishii
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Oct 19, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Alex Chang
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 22, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Viren AsherAnish Bali
Mar 24, 2012·Cancer Cell·Douglas Hanahan, Lisa M Coussens
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 23, 2013·Cancer Cell·Michele De Palma, Claire E Lewis
Apr 2, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Andreas CarusFrede Donskov
Nov 29, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Israel CañadasEdurne Arriola
Mar 19, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Quirino Lai, Jan Lerut
Aug 8, 2014·Frontiers in Immunology·Maria Muccioli, Fabian Benencia
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal

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