Predictive value of interim 18F-FDG-PET in patients with non-small cell lung cancer treated with definitive radiation therapy

PloS One
Nalee KimChang Geol Lee

Abstract

We evaluated that early metabolic response determined by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) during radiotherapy (RT), predicts outcomes in non-small cell lung cancer. Twenty-eight patients evaluated using pretreatment 18F-FDG-PET/CT (PETpre) and interim 18F-FDG-PET/CT (PETinterim) after 11 fractions of RT were retrospectively reviewed. Maximum standardized uptake value (SUVmax) was calculated for primary lesion. Predictive value of gross tumor volume (ΔGTV) and SUVmax (ΔSUVmax) changes was evaluated for locoregional control (LRC), distant failure (DF), and overall survival (OS). Metabolic responders were patients with ΔSUVmax >40%. Metabolic responders showed better trends in 1-year LRC (90.9%) than non-responders (47.1%) (p = 0.086). Patients with large GTVpre (≥120 cc) demonstrated poor LRC (hazard ratio 4.14, p = 0.022), while metabolic non-responders with small GTVpre (<120 cc) and metabolic responders with large GTVpre both had 1-year LRC rates of 75.0%. Reduction of 25% in GTV was not associated with LRC; however, metabolic responders without a GTV response showed better 1-year LRC (83.3%) than metabolic non-responders with a reduction in GTV (42.9%). Metabolic responders ...Continue Reading

References

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Citations

Dec 17, 2020·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Nalee KimYoung Seok Cho

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT03829007
NCT03853187
NCT02760225

Software Mentioned

ESPATUE
PET Edge
MIM
MIM Maestro
R
SPSS

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