Predictive value of long-term changes of growth differentiation factor-15 over a 27-year-period for heart failure and death due to coronary heart disease

PloS One
Nina FluschnikDirk Westermann

Abstract

Growth differentiation factor-15 (GDF-15), Cystatin C and C-reactive protein (CRP) have been discussed as biomarkers for prediction of cardiac diseases. The aim of this study was to investigate the predictive value of single and repeated measurements of GDF-15 compared to Cystatin C and CRP for incidence of heart failure (HF) and death due to coronary heart disease (CHD) in the general population. Levels of GDF-15, CRP and Cystatin C were determined in three repeated measurements collected 5 years apart in the DAN-MONICA (Danish-Multinational MONitoring of trends and determinants in Cardiovascular disease) cohort (participants at baseline n = 3785). Cox regression models adjusted for cardiovascular risk factors revealed significantly increased hazard ratios (HR) for GDF-15 for incident HF 1.36 (HR per interquartile range (IQR) increase, 95% confidence interval (CI): 1.16; 1.59) and for death from CHD 1.51 (HR per IQR increase, 95% CI: 1.31, 1.75) (both with p<0.001). Joint modeling of time-to-event and longitudinal GDF-15 over a median 27-year follow-up period showed that the marker evolution was positively associated with death of CHD (HR per IQR increase 3.02 95% CI: (2.26, 4.04), p < 0.001) and HF (HR per IQR increase 2.12 9...Continue Reading

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Citations

Oct 31, 2019·Critical Reviews in Clinical Laboratory Sciences·Maria ArkoumaniIoannis Papassotiriou
Jun 25, 2020·Journal of the American Heart Association·Sri Lekha TummalapalliUNKNOWN CRIC Study Investigators †
Mar 29, 2020·European Journal of Heart Failure·Navin SuthaharRudolf A de Boer
May 12, 2019·Critical Reviews in Clinical Laboratory Sciences·Stéphanie DesmedtMarijn M Speeckaert
Nov 24, 2020·Clinical Chemistry·Paul M HallerJohannes T Neumann
Jan 12, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Juliette TavenierJan O Nehlin
Jan 21, 2021·Frontiers in Cardiovascular Medicine·Germán CedielAntoni Bayes-Genis
Aug 28, 2021·International Journal of Molecular Sciences·Luc RochetteCatherine Vergely
Nov 18, 2018·International Journal of Radiation Oncology, Biology, Physics·Biniyam G DemisseiBonnie Ky

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