Predictive value of negative 3T multiparametric magnetic resonance imaging of the prostate on 12-core biopsy results

BJU International
James S WysockSamir S Taneja

Abstract

To evaluate the cancer detection rates for men undergoing 12-core systematic prostate biopsy with negative prebiopsy multiparametric magnetic resonance imaging (mpMRI) results. Clinical data from consecutive men undergoing prostate biopsy who had undergone prebiopsy 3T mpMRI from December 2011 to August 2014 were reviewed from an institutional review board-approved prospective database. Men with negative prebiospy mpMRI results (negMRI) before biopsy were identified for the present analysis. Clinical features, cancer detection rates and negative predictive values were summarized. Seventy five men with negMRI underwent systematic 12-core biopsy during the study period. In the entire cohort, men with no previous biopsy, men with previously negative biopsy and men enrolled in active surveillance protocols, the overall cancer detection rates were 18.7, 13.8, 8.0 and 38.1%, respectively, and the detection rates for Gleason score (GS) ≥7 cancer were 1.3, 0, 4.0 and 0%, respectively. The NPVs for all cancers were 81.3, 86.2, 92.0, and 61.9, and for GS ≥7 cancer they were 98.7, 100, 96.0 and 100%, respectively. A negative prebiopsy mpMRI confers an overall NPV of 82% on 12-core biopsy for all cancer and 98% for GS ≥7 cancer. Based on b...Continue Reading

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Citations

May 4, 2016·Abdominal Radiology·Arvin K GeorgePeter A Pinto
Sep 20, 2016·Future Oncology·Neil MendhirattaAndrew B Rosenkrantz
Dec 28, 2016·AJR. American Journal of Roentgenology·Andrew B RosenkrantzSamir S Taneja
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Sep 10, 2020·Abdominal Radiology·Vassili AnastayMichael Baboudjian
Oct 1, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Yifei ChengGong Cheng
Sep 15, 2016·BJU International·Leonard S Marks
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Nov 17, 2017·International Urology and Nephrology·Julie Y AnPeter A Pinto
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