Predictive value of PCT and IL-6 for bacterial infection in children with cancer and febrile neutropenia

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Hilde T van der GaliënWim J E Tissing

Abstract

Only a third of children with cancer and febrile neutropenia (FN) have a proven bacterial infection; nevertheless, most children are hospitalized and treated with intravenous antibiotics. Several biomarkers have been proposed as predictive markers for bacterial infection in this population. We aimed to evaluate the role of interleukin-6 (IL-6) and procalcitonin (PCT) in diagnosing bacterial infection in children with cancer and FN. The study population was derived from a prospective database (2006-2013, IL-8 study) comprising children with cancer who presented with FN. From stored plasma samples (taken at admission and/or at 12-24 h), we determined the PCT and IL-6 levels. Consequently, we explored their relation with the presence of bacterial infection (positive blood culture, radiologically documented infection or clinical bacterial focus). We predefined cutoff values at 60 ng/L for IL-6 and 0.25 ng/mL for PCT. Seventy-seven FN episodes in 55 children with cancer were included. In 18 episodes (23.4%), a bacterial infection was documented. Both at presentation and after 12-24 h, median values of IL-6 and PCT were significantly higher in patients with a bacterial infection compared to patients without a bacterial infection. Wit...Continue Reading

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Citations

Dec 12, 2020·Saudi Journal of Biological Sciences·Asad Aziz KhanHassib Narchi

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS Mac OS X
GraphPad
GraphPad Prism X

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