Predictive value of plasma asymmetric dimethylarginine, homocysteine, and high-sensitive CRP levels in occult coronary artery disease: A multidetector-row computed tomography study

Herz
E GürelY Başaran

Abstract

Multidetector-row computed tomography (MDCT) is an attractive noninvasive imaging modality for detecting coronary atherosclerotic plaques, which may be underestimated by conventional angiography. The aim of our study was to determine the predictive value of plasma asymmetric dimethylarginine (ADMA), homocysteine, and high-sensitivity C-reactive protein (hsCRP) levels for occult coronary artery disease (CAD). Thirty-five patients with angiographically normal coronary arteries (NCA) were consecutively included in our study. They underwent MDCT including indications and were divided into an NCA group (18 subjects, 8 male, 46 ± 8 years) and an occult CAD group (17 subjects, 11 male, 48 ± 9 years), with respect to the presence of coronary plaque. Plasma ADMA, homocysteine, and hsCRP levels were measured in blood samples. Plasma ADMA and homocysteine levels of the occult CAD group were significantly higher than those of the NCA group. A nonsignificant trend was observed for higher serum hsCRP levels in the occult CAD group. Receiver operating characteristics analysis revealed that an ADMA level of > 0.71 μmol/l could predict patients with occult CAD (sensitivity, 76 %; specificity, 67 %). The discriminative power of ADMA in distingui...Continue Reading

References

Apr 1, 1986·The Journal of Clinical Investigation·G Starkebaum, J M Harlan
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·R W EvansL H Kuller
Oct 26, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN Homocysteine Studies Collaboration
Jan 30, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·R J NijveldtP A M van Leeuwen
Dec 6, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Rainer H Böger
Apr 9, 2004·The New England Journal of Medicine·John DaneshVilmundur Gudnason
Jan 7, 2005·The New England Journal of Medicine·Steven E NissenUNKNOWN Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) Investigators
May 26, 2005·JAMA : the Journal of the American Medical Association·Martin H K HoffmannAndrik J Aschoff
Mar 20, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Eduard M LauferLeonard Hofstra

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