Predictive value of pretreatment albumin-to-alkaline phosphatase ratio for overall survival for patients with advanced non-small cell lung cancer.

Cancer Medicine
Shaozhang ZhouQitao Yu

Abstract

To investigate the relation between AAPR and OS in patients with advanced non-small cell lung cancer (NSCLC). A retrospective cohort study was conducted with 808 patients with advanced NSCLC who were treated in Guangxi Medical University Affiliated Tumor Hospital in China from 5 March 2009 to 31 August 2018. The target-independent and dependent variables were AAPR measured in patients before anticancer treatment and overall survival (OS), respectively. Covariates involved in this study included age, gender, ECOG status, smoking history, clinical stages, pathological type, driver mutation (EGFR or ALK), metastasis or not (bone, lung, liver, brain, malignant plural effusion, and other organs), number of organ metastasis(≤3, >3), first-line regiment and number of treatment lines (≤3, >3). The mean age of the selected patients was 58.3 ± 10.9 years and 68.6% were male. We divided patients according to their AAPR into low (AAPR < 0.34, n = 266), medium (AAPR = 0.34-0.47, n = 259), and high (AAPR > 0.47, n = 283) tertile groups. Medium and high AAPR were associated with a decreased risk of death after fully adjusted Cox proportional hazard model(s) with hazards ratio (HR) 0.77 (95%CI = 0.58-1.03) and HR 0.59 (95%CI = 0.45-0.78), resp...Continue Reading

References

Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Jul 31, 2012·Journal of Cancer Research and Therapeutics·Abhishek Singh Nayyar, Mubeen Khan
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Oct 17, 2017·International Journal of Colorectal Disease·Hsin-Yuan HungJy-Ming Chiang
Nov 13, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Tsutomu NamikawaKazuhiro Hanazaki
Feb 21, 2019·International Journal of Clinical Oncology·Yakup BozkayaFatih Gürler

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Citations

Jul 27, 2021·ACS Sensors·Kamonchanok PhoonsawatWijitar Dungchai

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