Predictive value of PTEN and AR coexpression of sustained responsiveness to hormonal therapy in prostate cancer--a pilot study.

Neoplasia : an International Journal for Oncology Research
Soha Salama El SheikhEl-Nasir Lalani

Abstract

One limitation of current biochemical or histologic analysis of advanced prostate cancer (PC; T(3)/T(4) +/- N(x) M(x)) is the ability to identify on first diagnostic biopsy patients who will make a durable response to hormone ablation therapy. The aim of this study was to assess the predictive value (sustained response to hormonal therapy and clinical outcome (relapse-free and overall survival)) of phosphatase and tensin homolog (PTEN) and the androgen receptor (AR) immunoexpression in the presenting biopsy. Analysis was performed on 47 samples (10 cases of benign prostatic hyperplasia and 37 hormone-naive PCs). Patients selected represented two stages in the natural history of PC: The "clinical metastatic androgen-responsive" (androgen-dependent PC, ADPC) and the "clinical metastatic androgen-resistant" (androgen-independent PC, AIPC). Reduced immunoreactivity (IR) of either or both PTEN/AR in the initial hormone-naive PC samples was observed with increased frequency in AIPCs. In the ADPC group, low PTEN and/or AR-IR was associated with a shorter median relapse-free survival, i.e., at 30 months after surgery, the probability of relapse-free survival for high expressors of PTEN and AR was 85.7% (SEM = 9.3) compared with only 16...Continue Reading

Citations

Nov 29, 2012·Journal of Cancer Research and Clinical Oncology·Naveen Kachroo, Vincent J Gnanapragasam
Dec 5, 2014·International Journal of Cancer. Journal International Du Cancer·Jayakumar S PoovasseryE Sally Ward
Nov 1, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mohammad Imran KhanHasan Mukhtar
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Aug 21, 2013·The Journal of Urology·Yota YasumizuMototsugu Oya
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Oct 17, 2020·NPJ Breast Cancer·Anna R MichmerhuizenCorey W Speers

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