PMID: 3772657Nov 1, 1986Paper

Predictive value of respiratory syncytial virus-specific IgE responses for recurrent wheezing following bronchiolitis

The Journal of Pediatrics
R C WelliverP L Ogra

Abstract

To determine whether the magnitude of the respiratory syncytial virus (RSV)-specific IgE response at the time of an episode of RSV bronchiolitis in infancy accurately predicts the development of subsequent wheezing episodes, we observed 38 infants prospectively from the time of an episode of infantile bronchiolitis through 48 months of age. Peak RSV-IgE titers were measured at the time of the bronchiolitis episode using an ELISA procedure. Notation was made of both the number of subsequent wheezing episodes reported by parents and the number documented by a physician. Subsequent wheezing was documented by a physician in 20% of infants who did not develop an RSV-IgE response at the time of the bronchiolitis episode and in 70% of those with the highest responses (P less than 0.025). These results suggest that the magnitude of the RSV-IgE response at the time of RSV bronchiolitis is a useful prognostic indicator for recurrent wheezing.

Citations

Mar 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E M Kudlacz, R W Knippenberg
Sep 1, 1992·European Journal of Pediatrics·M L Everard, A D Milner
Jan 24, 2002·Clinical Reviews in Allergy & Immunology·Anne L Wright
Apr 12, 2013·Clinical Reviews in Allergy & Immunology·Andrea T BorchersLaurel J Gershwin
Dec 19, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Scott L Osur
Apr 6, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R L MortonN S Eid
Oct 24, 2007·The Journal of Experimental Medicine·Mitchell H GraysonMichael J Holtzman
Jan 7, 2003·Viral Immunology·Svetlana F Khaiboullina, Stephen C St Jeor
Sep 1, 1995·Allergy·L C Martinati, A L Boner
May 1, 1994·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·E A Colocho ZelayaO Strannegård
May 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J ForsterU Wahn
Jan 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J L Kimpen
Jan 1, 1995·Archives of Disease in Childhood·S YoungL I Landau
Jan 1, 1995·Archives of Disease in Childhood·M L EverardA D Milner
Apr 1, 1997·Archives of Disease in Childhood·V NobleA D Milner
Jan 1, 1989·Thorax·A D Milner, M Murray
Apr 1, 1994·Thorax·L I Landau
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·P M RenziS Spier
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·N Sigurs
Mar 1, 1989·The American Review of Respiratory Disease·F M GrazianoW W Busse
Oct 1, 1989·The American Review of Respiratory Disease·W P Glezen
Dec 1, 1989·The American Review of Respiratory Disease·B Burrows, F D Martinez
Jul 1, 1991·The American Review of Respiratory Disease·S I BeerM J Waron
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·F D Martinez
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·R G HegeleP D Paré
Oct 1, 1995·American Journal of Respiratory and Critical Care Medicine·J E Gern, W W Busse
Oct 1, 1995·American Journal of Respiratory and Critical Care Medicine·S L Johnston
Sep 9, 2008·American Journal of Respiratory and Critical Care Medicine·Pingsheng WuTina V Hartert
Jul 19, 2011·American Journal of Respiratory and Critical Care Medicine·Lauren E Camarda, Mitchell H Grayson
Apr 1, 1991·American Journal of Respiratory Cell and Molecular Biology·W W BusseE C Dick
Oct 1, 1992·American Journal of Respiratory Cell and Molecular Biology·M A HuftelW W Busse
Jan 1, 1989·The Journal of Clinical Investigation·R F LemanskeW W Busse
May 29, 2008·Future Microbiology·Stephanie S ParkMitchell H Grayson
Jan 4, 2013·Paediatric Respiratory Reviews·Shelagh M SzaboIan Mitchell
Apr 17, 2010·The Journal of Allergy and Clinical Immunology·Patrick G Holt, Deborah H Strickland
Mar 8, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Brian T Kelly, Mitchell H Grayson
Oct 31, 2009·Allergologia et immunopathologia·F D Martinez
Dec 17, 2008·Allergologia et immunopathologia·J A Castro-Rodriguez, L Garcia-Marcos
Apr 14, 2009·The Journal of Allergy and Clinical Immunology·Kecia N CarrollTina V Hartert
Nov 30, 2015·BMC Medical Informatics and Decision Making·Gang LuoMichael D Johnson
Feb 12, 2010·Annals of the New York Academy of Sciences·Loralyn A Benoit, Michael J Holtzman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.