Predictive value of salivary microRNA-320a, vascular endothelial growth factor receptor 2, CRP and IL-6 in Oral lichen planus progression

Inflammopharmacology
Minoo ShahidiMohammad Saeed Gholami

Abstract

MicroRNA (miRNA) 320a and vascular endothelial growth factor receptor 2 (VEGFR-2) expression as the angiogenic biomarkers might be therapeutic targets in Oral lichen planus (OLP). IL-6 and C-reactive protein (CRP) could be prognostic in OLP, dysplastic OLP and Oral squamous cell carcinoma (OSCC). Therefore, their salivary detections as the noninvasive tools were aimed in this study. Histopathologic examinations were carried out to distinguish the patients with dysplastic OLP and OSCC. Salivary microRNA expression analysis was performed using RT-qPCR. IL-6 and CRP levels were also measured in saliva via ELISA method. VEGFR-2 expression in various sections was evaluated using immunohistochemistry. A significant decrease in salivary microRNA-320a in dysplastic OLP and OSCC but not in OLP without dysplasia was found. VEGFR-2 visualization confirmed the increasing angiogenic process in these cases. A significant increase in IL-6 level was detected in cases with OLP, dysplastic OLP and OSCC. CRP levels also showed a significant increase in dysplastic OLP and OSCC. A positive correlation between IL-6 and CRP levels was found. Identification of the salivary microRNA-320a and hs-CRP might provide a convenient noninvasive predictive tool...Continue Reading

References

Sep 20, 1993·Annals of the New York Academy of Sciences·M Navazesh
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Aug 18, 2004·Archives of Otolaryngology--head & Neck Surgery·Maie A R St JohnDavid T W Wong
Oct 20, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S WarnakulasuriyaI van der Waal
Feb 27, 2008·Oral Diseases·M A Gonzalez-MolesJ A Gil-Montoya
May 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lin ZhangGeorge Coukos
Mar 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Chih-Cheng ChenMiao-Fen Chen
Dec 3, 2010·The Journal of Pathology·Thalia A FaraziThomas Tuschl
Sep 13, 2011·Journal of the American Academy of Dermatology·Nita Chainani-WuSol Silverman
May 12, 2012·Annals of Surgical Oncology·Shiang-Fu HuangHsuan-Ho Chen
Oct 31, 2012·Cytokine & Growth Factor Reviews·Parvin Ataie-KachoieDavid L Morris
Dec 12, 2012·Medicina oral, patología oral y cirugía bucal·Serban TovaruAndrea Sardella
Jun 11, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Seyed Isaac HashemyMaryam Amirchaghmaghi
Oct 28, 2015·BioMed Research International·Anjie MinDipak Sapkota
Nov 4, 2015·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·R Metgud, S Bajaj

❮ Previous
Next ❯

Citations

Feb 10, 2019·Dentistry Journal·Hamed MortazaviSomayeh Rahmani
Jun 6, 2019·Inflammation·Amir FarzaneganMinoo Shahidi
Jul 18, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Farzad RezaeiMasoud Sadeghi
Jul 28, 2020·International Journal of Molecular Sciences·Lucía Melguizo-RodríguezRebeca Illescas-Montes
Feb 10, 2021·Journal of Personalized Medicine·Maria MeniniPaolo Pesce

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
fluorescence microscopy
PCR
ELISA

Software Mentioned

ImageJ
graph pad prism6
ImagJ

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Farzaneh Agha-HosseiniMohammad Abdollahi
Medicina oral, patología oral y cirugía bucal
Elba-Rosa Leyva-HuertaElisa Vega-Memije
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Lakshmi Mitreyi GorugantulaYi-Shing Lisa Cheng
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Yang LiuHong-wei Liu
© 2022 Meta ULC. All rights reserved