Mar 29, 2007

Predictive value of serial measurements of sTREM-1 in the treatment response of patients with community-acquired pneumonia

Journal of the Formosan Medical Association = Taiwan Yi Zhi
Wen-Cheng ChaoChieh-Liang Wu

Abstract

To evaluate the roles of plasma sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) and C-reactive protein (CRP) in predicting treatment response in patients with community-acquired pneumonia (CAP). Patients with CAP were enrolled prospectively at a medical center in central Taiwan from September 1, 2004 to July 31, 2005. They were treated according to the guidelines proposed by the American Thoracic Society. Patients were noted as nonresponsive to initial treatment if they had one of the following: persistent fever for more than 3 days, progression on chest radiograph, switching to other antibiotics, or need of mechanical ventilation and/or chest tube drainage. Fifty-eight patients (43 males/15 females; mean age, 67 +/- 21 years) with CAP were enrolled. Twelve (12/58, 21%) were nonresponsive. In the response group, CRP was reduced up to 58% from day 1 to day 3 (from 18.8 to 7.8 mg/dL), whereas sTREM-1 was reduced by only 15% (from 32.8 to 28.1 pg/mL). In the nonresponse group, CRP still declined 20% (from 22.2 to 17.7 mg/dL), whereas sTREM-1 was persistently high (from 61.7 to 63.7 pg/mL). Using multivariate logistic regression analysis, both CRP (p = 0.006) and sTREM-1 (p = 0.046) on day 3 predicted treatment r...Continue Reading

  • References14
  • Citations7

References

Mentioned in this Paper

C-reactive Protein Measurement
TREM1 protein, human
Immunologic Adjuvants
Adjuvant
Plain X-ray
Myeloid Cells
Differential White Blood Cell Count Procedure
Dissecting Aneurysm of the Thoracic Aorta
Anterior Thoracic Region
Soluble

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