Predictive Value of Some Inflammatory Indexes in the Survival and Toxicity of Nasopharyngeal Carcinoma

Cancer Management and Research
Yu-Yuan HanXiao-Dong Zhu

Abstract

The present study aimed to investigate the predictive value of some inflammatory indexes, such as the ratio of C-reactive protein-to-albumin (CAR), high-sensitivity C-reactive protein-to-albumin (HCAR), C-reactive protein-to-lymphocyte (CLR), and high-sensitivity C-reactive protein-to-lymphocyte (HCLR) in the survival and toxicity of nasopharyngeal carcinoma and provide reference for the development of treatment. A retrospective analysis was conducted on 162 patients from 2013 to 2018. The value of the indexes before the treatment was calculated. SPSS 25.0 software was used for the analysis, and the cutoff values of the indexes were determined by the receiver operating characteristic curve (ROC). The prognostic value of the indexes was evaluated according to the overall survival rate (OS), progression-free survival rate (PFS), and the incidence of toxic side effects. The index CLR was found to be the predictor of mortality of nasopharyngeal carcinoma but not the indicator for toxicity. The index CLR can be used for risk-stratification. However, whether the risk-stratification treatment based on these indicators can improve the prognosis subsequently needs further prospective study.

References

Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 18, 2015·Reviews on Recent Clinical Trials·Fausto PetrelliAlberto Zaniboni
Sep 1, 2015·Lancet·Melvin L K ChuaAnthony T C Chan
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne W M LeeAnthony T C Chan
Apr 29, 2016·Chinese Clinical Oncology·Wan-Ling TanMei-Kim Ang
Jan 5, 2018·Journal of Gastrointestinal Oncology·Yuchen WangAlfonso J Tafur
Feb 7, 2018·Journal of Hepatocellular Carcinoma·Marc NajjarKarim J Halazun

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