Predictive Value of Standardized Intratumoral Metabolic Heterogeneity in Locally Advanced Cervical Cancer Treated With Chemoradiation

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Fei YangPerry W Grigsby

Abstract

The aim of this study was to propose and evaluate a novel image metric for quantifying spatial heterogeneity of tumor 18F-fluorodeoxyglucose (FDG) uptake within the context of predicting response to chemoradiation in locally advanced cervical cancer. Ninety patients with locally advanced cervical cancer treated with concomitant chemoradiation were included in this study. Each patient underwent two whole-body 18F-FDG positron emission tomography/computed tomography scans with one before the initiation of treatment for staging and the other at 12 weeks after treatment completion for response assessment. Patients were categorized in terms of response to chemoradiation into two major groups: complete metabolic responders and noncomplete metabolic responders. The capacity of the proposed intratumoral heterogeneity metric to differentiate patients with respect to response to therapy was evaluated and compared with the use of standardized uptake value indices and various texture parameters that had been previously introduced for predicting tumor response to chemoradiation. At baseline, the proposed intratumoral heterogeneity metric along with four texture features, including entropy and energy derived from gray-level co-occurrence mat...Continue Reading

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Citations

Jun 27, 2018·Nuclear Medicine and Molecular Imaging·Jeong Won Lee, Sang Mi Lee
Sep 21, 2019·The British Journal of Radiology·Ulrike SchickMathieu Hatt

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