Predictive value of symptoms for early detection of ovarian cancer.

Journal of the National Cancer Institute
Mary Anne RossingNoel S Weiss

Abstract

A recent consensus statement encouraged use of certain symptoms to diagnose ovarian cancer earlier. We assessed the sensitivity, specificity, and positive predictive value of a proposed symptom index and of symptoms included in the consensus recommendation. In-person interviews were conducted with 812 case patients, aged 35-74 years, who had epithelial ovarian cancer that was diagnosed from January 1, 2002, through December 31, 2005, and with 1313 population-based control subjects. The symptom index was considered positive when pelvic or abdominal pain or bloating or feeling full was reported at least daily for at least 1 week, with an onset of less than 12 months before diagnosis or a reference date (for control subjects). The consensus criteria were considered fulfilled when any symptom above or urinary urgency or frequency was reported for at least 1 month, with an onset of less than 12 months before diagnosis or a reference date. Positive predictive value was calculated by use of external estimates of cancer prevalence. Most case patients who had a positive index or met consensus criteria did so only within 5 months before diagnosis. Symptoms (except nausea) were somewhat less likely to have occurred among women diagnosed w...Continue Reading

References

Dec 22, 1999·Gynecologic Oncology·G H EltabbakhP R Yadev
Nov 7, 2000·Cancer·B A GoffC H Melancon
Aug 17, 2001·Obstetrics and Gynecology·S H OlsonS Harlap
Jun 25, 2003·Gynecologic Oncology·Marilyn F VineJoellen M Schildkraut
Jan 31, 2004·Gynecologic Oncology·Penelope M WebbAdèle C Green
Apr 28, 2004·The American Journal of Pathology·Ie-Ming Shih, Robert J Kurman
May 29, 2004·American Journal of Obstetrics and Gynecology·Cara A AttanucciAnnette H Chen
Jun 10, 2004·JAMA : the Journal of the American Medical Association·Barbara A GoffHoward G Muntz
May 21, 2005·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Isam LataifehNeville F Hacker
Jun 21, 2005·Family Practice·Gary D FriedmanLloyd H Smith
Aug 24, 2005·Cancer·Lloyd H SmithPatrick S Romano
May 2, 2007·Obstetrics and Gynecology·A Blythe RyersonLisa C Richardson
Sep 13, 2007·Journal of the National Cancer Institute·Renee Twombly
Oct 2, 2007·Journal of Women's Health·Michelle L WynnLucy A Peipins
Dec 19, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mary Anne RossingNoel S Weiss
Mar 5, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Robert J Kurman, Ie-Ming Shih

❮ Previous
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Citations

Sep 11, 2010·Journal of the National Cancer Institute·Rodrigo Valdes, Giuseppe Del Priore
Sep 11, 2010·Journal of the National Cancer Institute·Susan J JordanUNKNOWN Australian Ovarian Cancer Study Group
Aug 30, 2012·Menopause : the Journal of the North American Menopause Society·Elisabeth A EreksonElena S Ratner
Feb 22, 2012·Clinical Obstetrics and Gynecology·Barbara Goff
Sep 14, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Koji MatsuoNeil B Rosenshein
Aug 22, 2012·JSLS : Journal of the Society of Laparoendoscopic Surgeons·Richard H Demir, Greg J Marchand
Sep 10, 2011·Clinical Medicine : Journal of the Royal College of Physicians of London·Ellen Welch
May 28, 2013·The Journal of Family Planning and Reproductive Health Care·Emma L LowAlice E Simon
Dec 18, 2012·Women's Health·Edward J Pavlik, John R van Nagell
Mar 13, 2013·Women's Health·Long NguyenDavid Fishman
Mar 19, 2011·Journal of Women's Health·Crystale Purvis CooperCynthia A Gelb
Feb 18, 2016·Journal of Women's Health·Chioma O EronduPatricia G Moorman
Feb 13, 2016·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·James DilleyUsha Menon
Jun 28, 2015·American Journal of Obstetrics and Gynecology·Eleanor L OrmsbyJohn R van Nagell
Jun 12, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·D Parkin, M Cruickshank
Nov 7, 2015·American Journal of Preventive Medicine·Mark H EbellTaylor J Radke
Dec 10, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·Yl Wan, Ej Crosbie
Sep 2, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Byung-Joon ParkIl-Han Kim
May 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dan-tong Liu
Mar 25, 2017·Diagnostics·Robert M OreEdward J Pavlik
Apr 28, 2017·Diagnostics·Christopher G Smith
Mar 12, 2017·Diagnostics·Lauren A BaldwinRachel W Miller
Jul 30, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·A P MahyuddinM Choolani
Sep 22, 2012·Obstetrics and Gynecology·Angela ChanAnna V Tinker
May 25, 2011·Obstetrics and Gynecology·James H Liu, Kristine M Zanotti
Apr 10, 2010·Journal of Gynecologic Oncology·Kidong KimJae Weon Kim
Nov 8, 2018·Endocrine-related Cancer·Mona AlharbiCarlos Salomon
May 20, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Gary W Jean, Jill M Comeau
Jan 19, 2019·Endocrinology·Serdar E BulunDaniela Matei
Jul 25, 2013·British Journal of Cancer·E L LowU Menon

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