Predictive value of the ATP chemosensitivity assay in epithelial ovarian cancer

Gynecologic Oncology
A T O'Meara, B U Sevin

Abstract

The aims of this study were to define the specific parameters of the ATP chemosensitivity assay which most accurately predict a patient's clinical response to chemotherapeutic agents in epithelial ovarian cancer and to assess the clinical utility of the ATP assay. In our laboratory from 1992 to 1994, fresh tumor specimens from patients with epithelial ovarian carcinomas were assayed with the ATP chemosensitivity assay (ATP-CSA) for their in vitro responses to several chemotherapeutic agents including cisplatin, paclitaxel, and cyclophosphamide. Clinical data on 161 of those patients including all follow-up assessments were then collected, and an investigator blinded to the in vitro assay results determined the patients' responses to chemotherapy. In order to determine which parameter of the assay was the best predictor of clinical response for each drug, receiver-operator characteristic (ROC) curves were constructed for several parameters, including the amount of cell kill at particular dosage levels of drug, the slope of the dose-response curve, and the IC50, or the average concentration of drug at which 50% of the cells were nonviable. The specific parameter of the ATP-CSA which was most predictive of clinical response differ...Continue Reading

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Citations

Jun 26, 2013·Purinergic Signalling·Geoffrey Burnstock, Francesco Di Virgilio
Aug 12, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P KornblithD Burholt
Aug 1, 2005·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Shin Myung KangJoo-Hang Kim
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Jun 5, 2003·Anti-cancer Drugs·Martina BreidenbachChristian M Kurbacher
Feb 6, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lan Ying LiYoung Tae Kim

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