PMID: 2110604Jan 1, 1990Paper

Predictive value of the single-breath nitrogen test for hospitalization due to respiratory disease

Lung
J VestboF V Rasmussen

Abstract

The relationship between indices of the single-breath nitrogen test (SBNT) measured in 1974 and hospitalization in the 9 year period 1977-1986 was examined in a random population sample of 876 men aged 46-69 years. Men who could not perform acceptable SBNT tracings had an increased risk of hospitalization due to respiratory disease in general. When age and smoking habits were controlled for, slope of phase III was significantly related to hospitalization due to respiratory disease in general and chronic obstructive pulmonary disease (COPD), whereas closing volume and closing capacity were marginally related to hospitalization due to respiratory disease in general but not to hospitalization due to COPD. The relationship between slope of phase III and hospitalization due to COPD remained significant after the forced expiratory volume in 1 sec (FEV1) was controlled for: odds ratio 1.4 per % N2/L (95% confidence interval 1.1-1.7). The effect of the slope of phase III was considered to be clinically insignificant, and we conclude that in a random population sample indices from only 1 SBNT do not provide prognostic information concerning hospitalization in addition to that provided by FEV1.

References

Jun 8, 1978·The New England Journal of Medicine·M CosioP T Macklem
May 1, 1988·The American Review of Respiratory Disease·J VestboF V Rasmussen
Feb 1, 1988·The American Review of Respiratory Disease·A S BuistL E McCamant
Oct 1, 1966·British Journal of Preventive & Social Medicine·G R McNabC J Stewart
May 1, 1967·Progress in Cardiovascular Diseases·A P Thal, J M Kinney
May 1, 1984·The American Review of Respiratory Disease·T H BeatyC A Newill

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Citations

Sep 28, 2010·American Journal of Respiratory and Critical Care Medicine·Zorana J AndersenOle Raaschou-Nielsen
Jul 16, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jørgen Vestbo, Peter Lange

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