Predictive value of Wada memory scores on postoperative learning and memory abilities in patients with intractable epilepsy

Journal of Neurosurgery
Fani AndelmanItzhak Fried

Abstract

Surgery for refractory epilepsy often bestows significant relief but may cause memory impairment. The risk of postoperative memory loss can be determined by the intracarotid amobarbital procedure, or the Wada test. Chemical inactivation of the hemisphere on the side of the lesion is usually performed first, followed by inactivation of the contralateral hemisphere. Patients who demonstrate adequate memory capacity of the contralateral hemisphere following deactivation of the ipsilateral hemisphere are considered good candidates for anterior temporal lobectomy. Evidence for the contribution of deactivating the contralateral healthy hemisphere remains inconclusive. The authors analyzed results in 32 patients with intractable epilepsy who had undergone a bilateral Wada test followed by an anterior temporal lobectomy and in whom the findings of both pre- and postsurgical neuropsychological evaluations were available. The Wada memory scores were correlated with the difference in scores between pre- and postsurgical standardized memory test scores. Analyses revealed no significant relationship between the Wada memory scores in the contralateral hemisphere and postsurgical changes in memory abilities. There was, however, a significant ...Continue Reading

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Citations

Aug 26, 2009·Epilepsia·Barbara C Jobst
Sep 8, 2012·Epilepsy Research and Treatment·Chusak Limotai, Seyed M Mirsattari
Mar 15, 2015·Epilepsy & Behavior : E&B·Chaturbhuj RathoreKurupath Radhakrishnan
Jul 22, 2008·Epilepsy & Behavior : E&B·S Marc TestaJason Brandt
Jun 2, 2012·Acta Neurologica Scandinavica·F AndelmanM Y Neufeld
Aug 30, 2006·Epilepsy & Behavior : E&B·Fani AndelmanMiri Y Neufeld
Dec 31, 2010·Epilepsy & Behavior : E&B·Ashwini SharanMichael R Sperling
Feb 18, 2011·The Annals of Pharmacotherapy·Akta PatelDorota Szarlej
Sep 10, 2010·British Journal of Neurosurgery·Takahiro OtaNobuhito Saito
May 3, 2019·Current Neurology and Neuroscience Reports·Andreu Massot-TarrúsSeyed M Mirsattari

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