Predictivity and sensitivity of animal models of arthritis

Autoimmunity Reviews
Rosanna Di Paola, Salvatore Cuzzocrea

Abstract

Arthritis literally means joint inflammation. Arthritis is not a single disease. Arthritis refers to a group of rheumatic diseases and other conditions that can cause pain, stiffness and swelling in the joints. The forms range from those related to wear and tear of cartilage (such as osteoarthritis) to those associated with inflammation resulting from an overactive immune system (such as rheumatoid arthritis). Arthritis is more heterogeneous and this is an important starting point when discussing animal models for arthritis. Animal models are instrumental in understanding the etiology and pathogenetic mechanisms of rheumatoid arthritis. Several new mouse models have either been produced. Various methods have been applied to induce in animals experimental models of arthritis which would provide important insights into the aetiopathogenetic mechanisms of human RA.

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Citations

Aug 14, 2012·Clinical Rheumatology·Yiping HuPeng Zhang
Dec 3, 2010·The Journal of Biological Chemistry·Rajesh RajaiahKamal D Moudgil
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Dec 4, 2012·Autoimmunity Reviews·Silvia FrisendaGuido Valesini
Feb 20, 2018·Journal of Dairy Science·Lan-Hsin HungLucy Sun Hwang
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Jan 28, 2020·The European Journal of Neuroscience·Mélanie KremerIpek Yalcin
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Jan 23, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alexandra M S CarvalhoLucindo J Quintans-Júnior

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