Predictor for histological microvascular invasion of hepatocellular carcinoma: a lesson from 229 consecutive cases of curative liver resection.

World Journal of Surgery
Susumu EguchiTakashi Kanematsu

Abstract

Microscopic vascular invasion is an important risk factor for recurrent hepatocellular carcinoma (HCC), even after curative liver resection or orthotopic liver transplantation. To predict microscopic portal venous invasion, the following two questions were examined retrospectively: Is it possible to detect microvascular invasion preoperatively? What are the characteristics of a group of early HCC recurrences even with no microvascular invasion? Study 1 included 229 patients with HCC who underwent curative liver resection between 1991 and 2008; 127 had HCC without microscopic portal venous invasion, and 52 had HCC with microscopic portal venous invasion (MPVI). These two distinct groups were analyzed with regard to various clinicopathologic factors. Subsequently, we specifically investigated if HCCs <5 cm with vascular invasion (n = 32) have some characteristics that would allow detection of latent microvascular invasion. Study 2 included 127 HCC patients without MVPI; 42 had a recurrence within 2 years, and 85 patients were recurrence-free for at least 2 years. These two distinct groups were analyzed with regard to various clinicopathologic factors. HCC diameter of >5 cm, the macroscopic appearance of HCC, and high levels of pr...Continue Reading

References

Sep 1, 1991·Annals of Surgery·S IwatsukiR Selby
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Sep 28, 2001·American Journal of Surgery·M ShimadaK Sugimachi
Aug 30, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francis Y YaoJohn P Roberts
Jan 28, 2006·World Journal of Gastroenterology : WJG·Bong-Wan KimMyung-Wook Kim
Dec 5, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masaaki HidakaTakashi Kanematsu

❮ Previous
Next ❯

Citations

Dec 29, 2011·Annals of Surgical Oncology·Yo-ichi YamashitaYoshihiko Maehara
Nov 15, 2012·Annals of Surgical Oncology·Manuel Rodríguez-PerálvarezAndrew Kenneth Burroughs
Oct 14, 2011·International Journal of Hepatology·Jendana ChanyaputhipongPierce K H Chow
Mar 29, 2014·Advanced Drug Delivery Reviews·Klazina KooimanNico de Jong
Jan 1, 2014·World Journal of Surgery·Nazario PortolaniStefano Maria Giulini
Aug 26, 2014·AJR. American Journal of Roentgenology·Chen-Te ChouYao-Li Chen
Aug 5, 2014·Magnetic Resonance Imaging Clinics of North America·Daniel C Barr, Hero K Hussain
Aug 11, 2011·The British Journal of Radiology·C-T ChouY-L Chen
Mar 17, 2016·Surgical Oncology·Fumitoshi HirokawaKazuhisa Uchiyama
Sep 4, 2015·Journal of Gastroenterology and Hepatology·Young Kul JungSoon Ho Um
Feb 4, 2012·Journal of Hepatology·Carlos Rodríguez de LopeJordi Bruix
May 3, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L ZhouQ Qu
Feb 27, 2016·Current Opinion in Organ Transplantation·Hae Won Lee, Kyung-Suk Suh
Jul 7, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Young Joo SuhKi Whang Kim
Jun 30, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Annette S H GouwMasamichi Kojiro
Mar 23, 2013·Journal of Gastroenterology and Hepatology·Dai Hoon HanKwang-Hyub Han
Apr 26, 2012·Journal of Magnetic Resonance Imaging : JMRI·Caroline D M WitjesJan N M Ijzermans
Jul 10, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Fumitoshi HirokawaKazuhisa Uchiyama
Apr 16, 2013·Journal of Clinical Pathology·Caroline D M WitjesJan N M IJzermans
Jul 6, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S M SchlichtemeierT J Hugh
Jun 25, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Shusuke OkamuraTakuji Torimura
Oct 13, 2016·Clinical and Molecular Hepatology·Hae Won Lee, Kyung-Suk Suh
Apr 1, 2017·Journal of Gastrointestinal Cancer·Hatem ElalfySahar Alsayed Mohamed Alsayed
Feb 15, 2017·European Journal of Gastroenterology & Hepatology·Xavier AdhouteMarc Bourlière
Dec 21, 2017·World Journal of Surgical Oncology·Yong Keun ParkHee-Jung Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.