Predictors and dynamics of posttraumatic epilepsy

Acta Neurologica Scandinavica
B Pohlmann-Eden, J Bruckmeir

Abstract

The goal of our study was to identify clinical, neurophysiological and neuroradiological variables in severe head trauma (SHT) with predictive value for posttraumatic epilepsy (PTE) and to evaluate the influence of each risk factor for the dynamics of epilepsy. We systematically compared 57 PTE patients with 50 age and sex-matched control patients with SHT and no PTE. Mean follow-up was 8 years. Of all PTE-patients 68.5% had their first seizure within 2 years after the trauma. Significant risk factors for PTE were focal signs in the first examination (P < 0.01), missile injuries (P < 0.01), frontal lesions (P < 0.01), intracerebral hemorrhage (P < 0.01), diffuse contusion (P < 0.01), prolonged posttraumatic amnesia (P < 0.001), depression fracture (P < 0.01) and cortical-subcortical lesions (P < 0.001). The combination of the last 3 variables conferred a particularly high risk for PTE (logistic regression analysis). Combined seizure pattern, high seizure frequency, AED-noncompliance and alcohol abuse predicted poor seizure control. The risk for PTE is clearly determined by those variables which correlate with the severity, the extent of tissue loss and the penetrating nature of the brain trauma.

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Citations

May 13, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ozkan AteşMahir Tevrüz
Mar 1, 2006·Journal of Neurotrauma·Asla Pitkänen, Tracy K McIntosh
Sep 17, 2013·Brain : a Journal of Neurology·Joyce S BalamiAlastair M Buchan
Aug 23, 2006·Epilepsia·Barbara E SwartzAntonio Delgado-Escueta
Jun 14, 2000·Drugs·A Iudice, L Murri
Nov 28, 2012·Journal of the American Veterinary Medical Association·Kristina S GrohmannMartin Kramer
May 19, 2007·Clinical Neurology and Neurosurgery·Jacques De ReuckGeorges Van Maele
Aug 27, 2005·The Psychiatric Clinics of North America·Barbara C Jobst, Peter D Williamson
Jun 3, 2020·Epilepsia·Jenny I SzuDevin K Binder
Jun 9, 2020·Brain Injury : [BI]·Hanna Siig HaustedLene Odgaard
Jan 12, 2017·Epilepsy & Behavior : E&B·Tao XuYangmei Chen
Apr 4, 2021·Seizure : the Journal of the British Epilepsy Association·Xue-Ping WangLing Liu

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