Predictors and outcomes for chronic tracheostomy after chemoradiation for advanced laryngohypopharyngeal cancer

The Laryngoscope
Gina D JeffersonMichael T Spiotto

Abstract

After concurrent chemoradiation for head and neck squamous cell cancer, patients with laryngeal incompetence may not recover function. We assessed variables predicting tracheostomy dependence as a measure of poor laryngeal function after chemoradiation. Retrospective Analysis of 109 patients treated with chemoradiation for locoregionally advanced laryngohypopharyngeal squamous cell cancers between 1992 and 2013. Median follow-up was 17.0 and 17.2 months for tracheostomy and nontracheostomy dependent patients, respectively. For all patients, multivariate analysis demonstrated persistent tracheostomy was associated with pretreatment tracheostomy, subglottic extension, three-dimensional conformal radiotherapy (3DCRT) and postradiotherapy lymphadenectomy. When analyzed by primary site, tracheostomy dependence was associated with pretreatment tracheostomy, subglottic extension, and 3DCRT in larynx primaries, and with pretreatment tracheostomy and feeding tube dependency in hypopharynx primaries. Tracheostomy dependence did not impact local control, progression-free survival or overall survival on univariate analysis. After curative chemoradiation, long-term tracheostomy was associated with pretreatment tracheostomy, subglottic exten...Continue Reading

References

Jun 13, 1991·The New England Journal of Medicine·UNKNOWN Department of Veterans Affairs Laryngeal Cancer Study GroupWilliam G Henderson
Aug 6, 2002·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jonathan StatonFrancisco Vieira
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David J AdelsteinArlene A Forastiere
Dec 3, 2003·The New England Journal of Medicine·Arlene A ForastiereJay Cooper
Apr 6, 2004·Otolaryngologic Clinics of North America·David Myssiorek
Jul 21, 2004·Archives of Otolaryngology--head & Neck Surgery·Ehab HannaJames Y Suen
Jan 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Gabriela StuderChristoph Glanzmann
Sep 7, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ozlem E Tulunay-UgurEmre Vural
Nov 28, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arlene A ForastiereJay S Cooper
Jul 31, 2014·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Zacharias VourexakisAnne-Marie Le Ridant

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Citations

Dec 20, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Abrahim Al-MamganiWillem Martin C Klop
May 8, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jolien HeukelomAbrahim Al-Mamgani
Jun 13, 2019·Radiation Oncology·Lukas AnschuetzOlgun Elicin
Jul 18, 2017·The Laryngoscope·Michael C TopfJoseph R Spiegel
Mar 5, 2020·Laryngoscope Investigative Otolaryngology·Ciaran LaneNorbert Viallet

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