Predictors and Risk of Ventricular Tachyarrhythmias or Death in Black and White Cardiac Patients: A MADIT-CRT Trial Substudy.

JACC. Clinical Electrophysiology
Avi SabbagValentina Kutyifa

Abstract

The study sought to analyze the risk of ventricular tachyarrhythmia (VTA) or death in black and white subjects implanted with implantable cardioverter-defibrillators (ICDs) or defibrillator and combined cardiac resynchronization therapy (CRT-D) in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation with Cardiac Resynchronization Therapy) trial. There are limited data on ethnic differences in the risk for VTA in mildly symptomatic heart failure patients with left ventricular dysfunction. The risk for first VTA (≥180 beats/min) or death was evaluated in black (n = 139) versus white (n = 1,638) patients enrolled in the MADIT-CRT trial using Kaplan-Meier survival analyses and Cox proportional hazards regression models after adjustment for relevant clinical covariates. Multivariate analysis was used to identify race-specific risk factors for VTA. At 4 years of follow-up, the cumulative probability for a first VTA or death was significantly higher among black patients (42%) as compared with whites (34%; log-rank p value for the overall difference during follow-up = 0.01). Multivariate analysis confirmed significantly higher risk of VTA or death (hazard ratio: 1.60; 95% confidence interval: 1.18 to 2.17; p = 0.002), and hi...Continue Reading

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References

Aug 26, 1993·The New England Journal of Medicine·L B BeckerJ Barrett
Nov 11, 1998·Journal of the American College of Cardiology·A W HaiderD Levy
Mar 26, 2003·Journal of the American College of Cardiology·Mark A EastEric D Peterson
Mar 7, 2007·Journal of Cardiovascular Electrophysiology·Grzegorz PietrasikWojciech Zareba
Feb 26, 2008·American Heart Journal·Judith E MitchellUNKNOWN SCD-HeFT Investigators
Jul 8, 2008·Neuroscience and Biobehavioral Reviews·Kevin P Davy, Jeb S Orr
Mar 20, 2009·The New England Journal of Medicine·Kirsten Bibbins-DomingoStephen B Hulley
Sep 3, 2009·The New England Journal of Medicine·Arthur J MossUNKNOWN MADIT-CRT Trial Investigators
Nov 16, 2010·The New England Journal of Medicine·Anthony S L TangUNKNOWN Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators
Feb 2, 2012·Circulation·Rajat Deo, Christine M Albert
Oct 9, 2012·Journal of the American College of Cardiology·Gregory OuelletIlan Goldenberg
Mar 28, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Meena ElanchennyIlan Goldenberg
Apr 1, 2014·The New England Journal of Medicine·Ilan GoldenbergArthur J Moss
Aug 15, 2014·The American Journal of Cardiology·Saurav ChatterjeeFranz H Messerli

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Citations

Jul 7, 2018·Journal of Cardiovascular Electrophysiology·Larry R JacksonValentina Kutyifa
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jan 30, 2020·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Feb 29, 2020·Journal of Cardiovascular Electrophysiology·Arwa YounisMehmet K Aktas
May 22, 2020·Circulation Research·Marie-Eve PichéJean-Pierre Després
Jan 28, 2021·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Apr 23, 2021·Circulation·Tiffany M Powell-WileyUNKNOWN American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; Co

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