Predictors for Identifying Burn Sepsis and Performance vs Existing Criteria

Journal of Burn Care & Research : Official Publication of the American Burn Association
David M HillWilliam L Hickerson

Abstract

Sepsis is the largest cause of mortality in thermally injured patients. Traditional systemic inflammatory response syndrome (SIRS) criteria do not aid diagnosis of sepsis in burn centers. Studies have attempted identification of the best indicators of sepsis in the thermal injured patient, but predictive variables are inconsistent across the various studies. Currently, consensus guidelines lack evidential support as to which patients will benefit most from prompt antimicrobial therapy. The purpose of our study was to evaluate novel diagnostic parameters for thermal injured patients with known sepsis and compare these parameters with existing diagnostic criteria. This study was a retrospective, electronic medical record review. Baseline demographics were analyzed utilizing chi-square, Mann-Whitney U test, or t test. Each patient served as their own control. Generalized linear mixed modeling was utilized for univariable and multivariable analysis. Several models with ≤6 variables each were built with the top performing variables. Performance was analyzed using area under receiver operating curves, sensitivity, specificity, positive predictive value, and negative predictive value. Three hundred and ninety-nine patients were screen...Continue Reading

References

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Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
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Jan 3, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·Brian K HoganClinton K Murray
Nov 9, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·Elizabeth A Mann-SalinasCharles E Wade
Feb 5, 2015·Burns : Journal of the International Society for Burn Injuries·Haitao RenHang Hu
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Mar 28, 2017·Journal of Burn Care & Research : Official Publication of the American Burn Association·David G Greenhalgh
Jun 4, 2017·Clinics in Plastic Surgery·David M HillWilliam L Hickerson

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Citations

Aug 11, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·David M HillTodd A Walroth
Oct 8, 2020·Surgical Infections·Luis Enrique Meza-EscobarMarc G Jeschke
Mar 15, 2021·Burns : Journal of the International Society for Burn Injuries·Simran R SinghSharmila Dissanaike
Feb 25, 2021·Journal of Burn Care & Research : Official Publication of the American Burn Association·Zhao ChenXiaolong Liu
Jul 18, 2021·Burns : Journal of the International Society for Burn Injuries·Chuanzhen XuLiqiang Wu

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