Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver disease.

United European Gastroenterology Journal
Helena Cortez-PintoFilipe Calinas

Abstract

The current standard of treatment in primary biliary cholangitis (PBC) is ursodeoxycholic acid (UDCA), although a considerable proportion of patients show incomplete response resulting in disease progression. This study aimed to assess the prevalence of incomplete response to UDCA and determine associated patients' characteristics. Patients with PBC as main diagnosis were included from a national multicentric patient registry-Liver.pt. Main endpoints included incomplete response to UDCA treatment according to Barcelona, Paris I and Paris II criteria, Globe and UK PBC scores and the association between baseline characteristics and incomplete response according to Paris II criteria. A total of 434 PBC patients were identified, with a mean age of 55 years and 89.2% females. Nearly half of patients were asymptomatic at diagnosis and 93.2% had positive anti-mitochondrial antibodies. Almost all patients (95.6%) had been prescribed at least one drug for PBC treatment. At the last follow-up visit, 93.3% were under treatment of which 99.8% received UDCA. Incomplete response to UDCA was observed in 30.7%, 35.3%, 53.7% and 36.4% of patients according to Barcelona, Paris I, Paris II criteria and Globe score, respectively. After adjusting f...Continue Reading

References

Aug 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christophe CorpechotRaoul Poupon
Oct 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert P MyersHude Quan
May 3, 2011·Lancet·Carlo SelmiRoss L Coppel
Jun 28, 2011·Journal of Hepatology·Christophe CorpechotRaoul Poupon
Jul 23, 2013·Journal of Autoimmunity·Mauro PoddaPietro Invernizzi
Jan 16, 2014·Autoimmunity Reviews·Christopher L Bowlus, M Eric Gershwin
Feb 13, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Eirini I Rigopoulou, Dimitrios P Bogdanos
Aug 1, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marco CarboneUNKNOWN UK-PBC Consortium
Sep 15, 2015·Lancet·Elizabeth J CareyKeith D Lindor
Oct 5, 2015·Clinics and Research in Hepatology and Gastroenterology·Ulrich BeuersRaoul Poupon
Jul 3, 2016·BMJ : British Medical Journal·Eugene C NelsonStaffan Lindblad
Jul 13, 2016·United European Gastroenterology Journal·Hedwig Ma D'AgnoloJoost Ph Drenth
Jul 21, 2016·Digestive Diseases and Sciences·Vinod S HegadeDavid E J Jones
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Aug 28, 2018·Journal of Clinical Gastroenterology·Zobair M YounossiAndrei Racila
Dec 26, 2018·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Marco MarzioniDomenico Alvaro
Jan 8, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Angela C CheungUNKNOWN Global PBC Study Group
Feb 10, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Akira HondaUNKNOWN Japan PBC Study Group

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