Predictors for regional lymph node metastasis in T1 rectal cancer: a population-based SEER analysis

Surgical Endoscopy
Walter BrunnerRene Warschkow

Abstract

Local resection of early-stage rectal cancer significantly reduces perioperative morbidity compared with radical resection. Identifying patients at risk of regional lymph node metastasis (LNM) is crucial for long-term survival after local resection. Patients after oncological resection of T1 rectal cancer were identified in the Surveillance, Epidemiology, and End Results register 2004-2012. Potential predictors of LNM and its impact on cancer-specific survival were assessed in logistic and Cox regression with and without multivariable adjustment. In total, 1593 patients with radical resection of T1 rectal cancer and a minimum of 12 retrieved regional lymph nodes were identified. The overall LNM rate was 16.3 % (N = 260). A low risk of LNM was observed for small tumor size (P = 0.002), low tumor grade (P = 0.002) and higher age (P = 0.012) in multivariable analysis. The odds ratio for a tumor size exceeding 1.5 cm was 1.49 [95 % confidence interval (CI) 1.06-2.13], for G2 and G3/G4 carcinomas 1.69 (95 % CI 1.07-2.82) and 2.72 (95 % CI 1.50-5.03), and for 65- to 79-year-old and over 80-year-old patients 0.65 (95 % CI 0.43-0.96) and 0.39 (95 % CI 0.18-0.77), respectively. Five-year cancer-specific survival for patients with LNM wa...Continue Reading

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Jul 25, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Ko-Chao LeeChien-Chang Lu
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Jun 18, 2021·Frontiers in Oncology·Yansong XuWeizhong Tang
Jul 11, 2021·The British Journal of Surgery·A L EbbehøjH G Smith

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