May 31, 2020

Predictors for Severe COVID-19 Infection

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Ashish BhargavaLouis Saravolatz

Abstract

COVID-19 is a pandemic disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Predictors for severe COVID-19 infection have not been well defined. Determination of risk factors for severe infection would enable identifying patients who may benefit from aggressive supportive care and early intervention. We conducted a retrospective observational study of 197 patients with confirmed COVID-19 infection admitted to a tertiary academic medical center. Of 197 hospitalized patients, the mean (SD) age of the cohort was 60.6 (16.2) years, 103 (52.3%) were male and 156 (82.1%) were black. Severe COVID-19 infection was noted in 74 (37.6%) patients, requiring intubation. Patients aged above 60 were significantly more likely to have severe infection. Patients with severe infection were significantly more likely to have diabetes, renal disease, chronic pulmonary disease and had significantly higher white blood cell counts, lower lymphocyte counts, and increased C-reactive protein (CRP) compared to patients with non-severe infection. In multivariable logistic regression analysis, risk factors for severe infection included pre-existing renal disease (odds ratio [OR], 7.4; 95% CI 2.5-22.0), oxygen r...Continue Reading

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Mentioned in this Paper

Supportive Care
S protein, severe acute respiratory syndrome coronavirus
African American
Acute Kidney Injury
Academic Medical Centers
Kidney Diseases
Acute Respiratory Disease
Determination Aspects
Cohort
Intubation

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