Predictors of adverse outcome in cancer patients with candidemia

The American Journal of Medicine
E AnaissieS Vartivarian

Abstract

Many factors, including severity of illness, neutropenia, intravenous catheter management, and drug therapy may affect the outcome of candidemia in cancer patients. The records of all patients at M. D. Anderson Cancer Center who developed one or more positive blood cultures for Candida spp between January 1, 1988, and December 31, 1992, were retrospectively reviewed. Four hundred ninety-one episodes of candidemia were identified, for which 476 had complete medical records, which were reviewed in detail. By 3-month follow-up, 52% of the patients had died. Neutropenia, higher APACHE III score, and visceral dissemination were associated with poor prognosis. Cure rates, adjusted for severity of illness, were similar for fluconazole and amphotericin B treatment. Exchange of central venous catheters was associated with a modest improvement in prognosis. Several factors that influence the outcome of candidemia in cancer patients have been identified. These factors may be relevant for the clinical management of cancer patients with candidemia, and for the design of therapeutic trials.

References

Jun 9, 1977·The New England Journal of Medicine·D G MakiH W Sarafin
Sep 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·V J FraserW C Dunagan
Apr 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A LeccionesT J Walsh
Oct 1, 1989·Archives of Internal Medicine·S B WeyR P Wenzel
May 1, 1974·Annals of Internal Medicine·R C YoungA S Levine
Jun 1, 1966·Journal of Chronic Diseases·G P Bodey
Nov 1, 1984·Critical Care Medicine·J R Le GallD Villers
Oct 1, 1993·The American Journal of the Medical Sciences·P MartinoF Mandelli
Aug 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E J BowB Schacter
Aug 1, 1996·The American Journal of Medicine·E J AnaissieG P Bodey
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D Abi-SaidS Vartivarian

❮ Previous
Next ❯

Citations

Nov 1, 2003·The Lancet Infectious Diseases·Philippe EggimannDidier Pittet
Nov 1, 2003·The Lancet Infectious Diseases·Nina Singh
Mar 14, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David R AndesUNKNOWN Mycoses Study Group
Mar 14, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cornelius J Clancy, M Hong Nguyen
Apr 17, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L A MermelUNKNOWN Society for Healthcare Epidemiology of America
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K A Marr, R A Bowden
Oct 1, 2005·Intensive Care Medicine·Philippe EggimannJorge Garbino
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·R SantangeloD S Perlin
Apr 16, 2004·Clinical Microbiology Reviews·Erna M Kojic, Rabih O Darouiche
Apr 24, 2004·Antimicrobial Agents and Chemotherapy·Matthew K SchinabeckMahmoud A Ghannoum
Jun 23, 2004·Emerging Infectious Diseases·Duncan M KuhnMahmoud A Ghannoum
Jan 28, 2005·Antimicrobial Agents and Chemotherapy·Ying-Ying CaoYuan-Ying Jiang
Oct 6, 2006·Journal of Clinical Microbiology·Juan LiFeng-Yan Bai
Dec 7, 2006·BMC Infectious Diseases·Donghui T YuDavid W Bates
Nov 4, 2009·Antimicrobial Agents and Chemotherapy·Ying TaurSusan K Seo
Jan 1, 2006·The Libyan Journal of Medicine·Ka Al-Anazi, Am Al-Jasser
Dec 4, 2003·The Lancet Infectious Diseases·Philippe EggimannDidier Pittet
Jan 31, 2009·Medical Mycology·Bradley J AtkinsonDimitrios P Kontoyiannis
May 24, 2005·The Journal of Infection·Mark J DiNubileNicholas A Kartsonis
Mar 7, 2000·The Journal of Antimicrobial Chemotherapy·I Raad
Mar 6, 2010·The Journal of Antimicrobial Chemotherapy·Monica A SlavinUNKNOWN Australian Candidemia Study, Australasian Society for Infectious Diseases
Aug 15, 2001·Folia Microbiologica·D TrubenováL Tkáciková
Sep 14, 2002·Current Infectious Disease Reports·Brad Spellberg, John E. Edwards
Nov 30, 2000·Current Infectious Disease Reports·C M Toscano, W R Jarvis
Nov 28, 2001·Current Infectious Disease Reports·Christopher J. Crnich, Dennis G. Maki
Feb 1, 2002·Diagnostic Microbiology and Infectious Disease·Damon P EisenBertil Christensson
Nov 2, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L Ostrosky-ZeichnerD N Buell
Jun 13, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E Velasco, R Bigni
Jul 25, 2008·Future Microbiology·Amy ChangDavid Horn
Jan 26, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marcio Nucci, Elias Anaissie
Sep 25, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D P KontoyiannisI I Raad
Nov 10, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Nucci, E Anaissie
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
Jun 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H RexT Wu
May 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·O UzunJ H Rex

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.