Predictors of alternative antidepressant agent initiation among U. S. veterans diagnosed with depression.

Pharmacoepidemiology and Drug Safety
Hyungjin Myra KimMarcia Valenstein

Abstract

Naturalistic studies comparing differences in risks across antidepressant agents must take into account factors which influence selection of specific agents and may be associated with outcomes. We examined predictors of antidepressant choice among VA patients treated for depression. Retrospective cohort study of VA patients with depression diagnoses and a new start of one of the seven most commonly prescribed antidepressant agents between 1 April 1999 and 30 September 2004 (n = 502 179). We examined the relationship between patient and facility characteristics and new starts of bupropion, citalopram, fluoxetine, mirtazapine, paroxetine, sertraline, and venlafaxine. We also examined factors associated with new starts only among patients starting selective serotonin reuptake inhibitors (SSRIs). Thirty-three percent of patients starting mirtazapine had at least three outpatient mental health visits in the prior year, compared to ≤ 24% of patients prescribed other antidepressants. Patients starting mirtazapine were also most likely to have received at least two other psychotropic medications in the prior year. Of the four SSRIs, 40% of the patients receiving sertraline and only 31% of those receiving fluoxetine were 65 years or old...Continue Reading

References

Mar 22, 2001·British Journal of Clinical Pharmacology·W E MeijerH G Leufkens
Nov 27, 2001·British Medical Bulletin·I M Anderson
Feb 26, 2003·Social Science & Medicine·Betsy Sleath, Ya-Chen Tina Shih
Jul 2, 2004·The American Journal of Psychiatry·Mark ZimmermanSteve Singer
Jul 2, 2005·Journal of Psychiatric Practice·G S AlexopoulosR W Ross

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Citations

Jun 1, 2012·Current Psychiatry Reports·Gerald GartlehnerRichard A Hansen
May 1, 2012·Journal of Clinical Psychopharmacology·Marcia ValensteinJohn F McCarthy
Aug 9, 2012·Journal of the American Medical Informatics Association : JAMIA·Khaled El EmamMurat Kantarcioglu
May 31, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N N IvanetsA V Lukyanova

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