Predictors of Antimicrobial Resistance among Pathogens Causing Urinary Tract Infection in Children

The Journal of Pediatrics
Nader ShaikhEllen R Wald

Abstract

To determine which children with urinary tract infection are likely to have pathogens resistant to narrow-spectrum antimicrobials. Children, 2-71 months of age (n = 769) enrolled in the Randomized Intervention for Children with Vesicoureteral Reflux or Careful Urinary Tract Infection Evaluation studies were included. We used logistic regression models to test the associations between demographic and clinical characteristics and resistance to narrow-spectrum antimicrobials. Of the included patients, 91% were female and 76% had vesicoureteral reflux. The risk of resistance to narrow-spectrum antibiotics in uncircumcised males was approximately 3 times that of females (OR 3.1; 95% CI 1.4-6.7); in children with bladder bowel dysfunction, the risk was 2 times that of children with normal function (OR 2.2; 95% CI 1.2-4.1). Children who had received 1 course of antibiotics during the past 6 months also had higher odds of harboring resistant organisms (OR 1.6; 95% CI 1.1-2.3). Hispanic children had higher odds of harboring pathogens resistant to some narrow-spectrum antimicrobials. Uncircumcised males, Hispanic children, children with bladder bowel dysfunction, and children who received 1 course of antibiotics in the past 6 months were...Continue Reading

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Citations

Nov 28, 2017·Journal of Clinical Gastroenterology·Jennifer N Addo SmithAmelia K Sofjan
Apr 2, 2019·The Cochrane Database of Systematic Reviews·Gabrielle Williams, Jonathan C Craig
Aug 17, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michelle MahonySean E Kennedy
Feb 21, 2019·The Cochrane Database of Systematic Reviews·Gabrielle WilliamsJonathan C Craig
Jul 31, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Elsa Roldan-MasedoAna Méndez-Echevarría
Feb 17, 2021·Journal of Pediatric Urology·Lisette A 't HoenRaimund Stein
Feb 19, 2021·Irish Journal of Medical Science·Mansoor AhmedTimothy Reynolds
Jan 23, 2021·Pediatrics·Tej K MattooCaleb P Nelson
Aug 2, 2018·Pediatrics·Annabelle de St MauriceSherry Ross

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