PMID: 15231551Jul 3, 2004Paper

Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders

The British Journal of Psychiatry : the Journal of Mental Science
Diana O PerkinsHGDH Research Group

Abstract

Duration of untreated psychosis (DUP) may contribute to the observed heterogeneity of the treatment response in first-episode schizophrenia. To examine the relationship of DUP and premorbid function with clinical outcomes following up to 2 years of antipsychotic treatment. For a subsample (n=191) of subjects participating in a clinical trial, DUP and premorbid function were prospectively compared with clinical response to olanzapine or haloperidol. Shorter DUP and good premorbid function each independently are associated with better clinical response, including improvement in overall psychopathology and negative symptoms. Premorbid function also is associated with positive symptom, social and vocational outcomes. Earlier antipsychotic treatment is associated with better outcomes in first-episode schizophrenia. Poor premorbid function could indicate an illness subtype less likely to respond to antipsychotic treatment regardless of when it is instituted.

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Jun 1, 1976·Australian and New Zealand Journal of Medicine·S D'SouzaR H Muntz
Sep 1, 1992·The American Journal of Psychiatry·A D LoebelS R Szymanski
Aug 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·E C JohnstoneT J Crow
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Jan 1, 1984·Schizophrenia Bulletin·D W HeinrichsW T Carpenter
Jan 1, 1982·Schizophrenia Bulletin·H E Cannon-SpoorR J Wyatt
Mar 21, 2001·Biological Psychiatry·J LiebermanR Bilder
Apr 13, 2002·Schizophrenia Research·Ashok K MallaJatinder Takhar
Nov 7, 2002·Archives of General Psychiatry·Wiepke CahnRené S Kahn

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Citations

Oct 26, 2007·Social Psychiatry and Psychiatric Epidemiology·Matthew Large, Olav Nielssen
May 28, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ofer AgidGary Remington
Aug 30, 2008·Schizophrenia Bulletin·Maria J Arranz, Shitij Kapur
Apr 28, 2006·Current Opinion in Psychiatry·Richard J Drake, Shôn W Lewis
Apr 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Andrzej CechnickiAnna Bielańska
Sep 24, 2011·The Journal of Clinical Psychiatry·Juan A GallegoJohn M Kane
Nov 12, 2013·Social Psychiatry and Psychiatric Epidemiology·Kelly K AndersonKwame McKenzie
Sep 2, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Thomas R E BarnesEileen M Joyce
Feb 5, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Ragy R GirgisJeffrey A Lieberman
Aug 4, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Anthony P MorrisonDouglas Turkington
Jan 1, 2006·International Journal of Psychiatry in Clinical Practice·Michael T ComptonMark Olfson
Sep 7, 2013·Journal of Medical Economics·Marie-Hélène LafeuilleMei Sheng Duh
Jan 1, 2005·International Journal of Psychiatry in Clinical Practice·Martin LambertBenno Graf Schimmelmann
Aug 2, 2008·Expert Opinion on Pharmacotherapy·Christian G HuberMartin Lambert
Sep 15, 2015·Expert Opinion on Drug Metabolism & Toxicology·Venuja SriretnakumarDaniel J Müller
Dec 17, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·B Dell'OssoA C Altamura
Sep 22, 2005·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Peter FalkaiUNKNOWN WFSBP Task Force on Treatment Guidelines for Schizophrenia
May 12, 2012·Journal of Psychiatric Research·Diego NovickEnric Alvarez
Mar 13, 2012·Journal of Affective Disorders·Amal Abdel-BakiAshok Malla
Mar 6, 2012·General Hospital Psychiatry·Janardhanan C NarayanaswamySuresh Bada Math
Apr 2, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·C U CorrellM Zink
Dec 25, 2009·Psychiatry Research·Javier Vázquez-BourgonBenedicto Crespo-Facorro
Aug 4, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tomas KasparekEva Ceskova
Apr 9, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jihyung HongJacqueline Brown
Jul 4, 2008·L'Encéphale·J-Y RotgéJ Tignol
Oct 2, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·Luis SanInmaculada Gilaberte
Jan 4, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chi-Un Pae
Apr 28, 2006·Acta Psychiatrica Scandinavica·A WunderinkD Wiersma
Mar 3, 2012·Early Intervention in Psychiatry·Maria Teresa CascioAngelo Cocchi
Aug 21, 2010·Acta Psychiatrica Scandinavica·Erik SimonsenT H McGlashan
Jun 14, 2005·Schizophrenia Research·Stephen M StrakowskiUNKNOWN HGDH Research Group
May 2, 2014·Psychiatry Research·Ross M G NormanDeborah Windell
Feb 26, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Benedicto Crespo-FacorroJosé Luis Vázquez-Barquero
Jul 28, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Alkomiet HasanUNKNOWN World Federation of Societies of Biological Psychiatry (WFSBP) Task Force on Treatment Guidelines for Schizophrenia

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