Predictors of asymptomatic Clostridium difficile colonization on hospital admission

American Journal of Infection Control
Ling Yuan KongVivian G Loo

Abstract

Clostridium difficile (CD) is the leading cause of health care-associated diarrhea and can result in asymptomatic carriage. Rates of asymptomatic CD colonization on hospital admission range from 1.4%-21%. The objective of this study was to evaluate host and bacterial factors associated with colonization on admission. The Consortium de recherche québécois sur le Clostridium difficile study provided data for analysis, including demographic information, known risk factors, and potential confounding factors, prospectively collected for 5,232 patients from 6 hospitals in Quebec and Ontario over 15 months from 2006-2007. Stool or rectal swabs were obtained for culture on admission. Pulsed-field gel electrophoresis was performed on the isolates. The presence of antibody against CD toxins A and B was measured. There were 212 (4.05%) patients colonized with CD on admission, and 5,020 patients were not colonized with CD. Multivariate logistic regression analysis showed that hospitalization within the last 12 months, use of corticosteroids, prior CD infection, and presence of antibody against toxin B were associated with colonization on admission. Of patients colonized on admission, 79.4% had non-NAP1, non-NAP2 strains. There are identifi...Continue Reading

References

Jan 26, 1989·The New England Journal of Medicine·L V McFarlandW E Stamm
Feb 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M H SamoreA W Karchmer
May 23, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S Johnson, D N Gerding
Sep 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carlene A Muto
Oct 31, 2008·The New England Journal of Medicine·Ciarán P Kelly, J Thomas LaMont
Nov 26, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Ajay K SethiCurtis J Donskey
Mar 24, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Stuart H CohenUNKNOWN Infectious Diseases Society of America
Aug 4, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Rodica GilcaMarc Dionne
Nov 4, 2011·The New England Journal of Medicine·Vivian G LooAndre Dascal
Jul 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fernanda C LessaL Clifford McDonald
Nov 7, 2012·Mayo Clinic Proceedings·Mira T KeddisQi Qian
Apr 30, 2013·American Journal of Infection Control·Surbhi LeekhaRobert Orenstein
Jul 25, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Scott R CurryLee H Harrison
Sep 27, 2013·The New England Journal of Medicine·David W EyreA Sarah Walker
Apr 24, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Faisal AlasmariErik R Dubberke

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Citations

Jul 15, 2015·Journal of Gastroenterology·Rowena AlmeidaElaine O Petrof
Nov 18, 2015·BMC Infectious Diseases·Luis Furuya-KanamoriArchie C A Clements
Jul 15, 2015·Digestive Diseases and Sciences·Stephen M Vindigni, Christina M Surawicz
Oct 30, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L Furuya-KanamoriT V Riley
May 19, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel A CaroffMichael Klompas
Jul 7, 2015·The American Journal of Gastroenterology·Claude Matuchansky
May 31, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Katherine LinsenmeyerKalpana Gupta
May 31, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Justin J O'Hagan, L Clifford McDonald
Feb 18, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Janice ChoRobin Patel
Jul 28, 2016·Expert Review of Anti-infective Therapy·Emilio BouzaElena Reigadas
Mar 16, 2018·Clinical Microbiology Reviews·Monique J T CrobachEd J Kuijper
Sep 17, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jack KeeganL Silvia Munoz-Price
Apr 26, 2018·Frontiers in Microbiology·Holger Schäffler, Anne Breitrück
Oct 30, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Scott AnjewierdenAbhishek Deshpande
Dec 31, 2020·International Journal of Molecular Sciences·Mia StromSarah Shigdar
Aug 8, 2021·Infectious Disease Clinics of North America·Philip C Carling
Dec 11, 2021·Pediatric Annals·Jacob M ParnellStacy A Kahn

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