Predictors of biochemical aspirin and clopidogrel resistance in patients with ischemic stroke

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Joanna FongRishi Gupta

Abstract

Variable platelet response to aspirin and clopidogrel is a well-established phenomenon in patients with coronary artery disease. We sought to determine the predictors of an impaired biochemical response to aspirin and clopidogrel in patients with ischemic stroke. Patients with established cerebrovascular disease who underwent an aspirin/clopidogrel response panel (ie, light transmittance aggregometry) between June 2003 and March 2007 were identified through an electronic database. The medical records of these patients were retrospectively reviewed, and demographic characteristics, medical history, and laboratory results were recorded. Univariate and multivariate logistic regression analyses were performed to assess for factors associated with antiplatelet resistance. Of the 465 patients included in this study, 120 (28%) were biochemical aspirin nonresponders and 83 (28%) were biochemical clopidogrel nonresponders. Of the 270 patients on dual antiplatelet therapy, 25 (9.3%) were dual biochemical nonresponders. In binary logistic regression modeling, patients with congestive heart failure (odds ratio [OR] = 4.54; 95% confidence interval [CI] = 1.33-15.5; P = .02) and those with higher hemoglobin A1c values (OR = 1.41; 95% CI = 1....Continue Reading

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Citations

Nov 8, 2011·Journal of Thrombosis and Thrombolysis·Feifei MaJunbiao Chang
Jan 10, 2013·Current Neurology and Neuroscience Reports·Ruth M Thomson, David C Anderson
Jul 11, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Nalyaka SambuNick Curzen
Dec 14, 2011·Thrombosis and Haemostasis·Saskia H MevesHorst Neubauer
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Jan 11, 2014·Thrombosis Research·Saskia H MevesHorst Neubauer
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Aug 5, 2019·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Malgorzata A KochanekMary Hammes
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Sep 5, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Se-Uk KwonYoung-Mi Lee
May 18, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Vafa AlakbarzadeAnthony C Pereira
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Apr 11, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Eva JoverJosé Rivera

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