Predictors of bone mineral density in patients on hemodialysis

Transplantation Proceedings
D ZayourG El-Hajj Fuleihan

Abstract

Renal osteodystrophy is a universal complication of uremia. Renal failure patients are at risk for low bone mineral density (BMD) and fractures. Parathyroid hormone (PTH) plays a pivotal role in the pathophysiology of uremic bone disease. Histomorphometric studies suggest that the maintenance of PTH levels between two and four times the upper limit of normal is associated with the lowest prevalence of two common forms of osteodystrophy: osteitis fibrosa cystica and adynamic bone disease. The purpose of this study was to investigate whether the above recommendation for PTH levels in dialysis patients corresponds to a more optimal BMD with a special emphasis on diabetic versus nondiabetic subjects. Twenty-eight patients with chronic renal failure on hemodialysis underwent measurement of PTH levels, as well as BMD at the lumbar spine, hip, and forearm. They were divided into three groups based on the mean PTH level over the 5 years prior to having BMD measured. Osteoporosis was diagnosed in 55% of men and 87% of women on dialysis. Predictors of BMD were gender, duration on hemodialysis, and diabetes. Our study supports the histomorphometry-based studies suggesting that the maintenance of intact PTH levels two to four times the upp...Continue Reading

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Citations

Sep 26, 2008·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Miljanka VuksanovićBranka Zerajić
Dec 30, 2009·International Urology and Nephrology·Csaba AmbrusIstvan Mucsi
Apr 17, 2012·Ultrasound in Medicine & Biology·Joanna ZywiecJanusz Gumprecht
Mar 10, 2010·Ultrasound in Medicine & Biology·Chiung-Wen KuoTieh-Chi Chu
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Feb 11, 2016·Journal of Strength and Conditioning Research·Sandra M MarinhoDenise Mafra

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