Predictors of Bothrops jararaca venom allergy in snake handlers and snake venom handlers

Toxicon : Official Journal of the International Society on Toxinology
Carlos R de MedeirosFábio F M Castro

Abstract

Since allergic sensitization to snake venom has been reported, anaphylactic reactions to snake venom might be an underestimated factor contributing to fatal snakebites, independently from the toxicity of the venom itself. However, little information is available on the determinants of such reaction. Hence, we studied a group of workers exposed to Bothrops jararaca venom (BJV), in order to clarify the factors related with snake venom allergy. The aim of this work was to investigate the prevalence and predictors of venom allergy among workers exposed to BJV and to confirm the involvement of IgE-mediated mechanisms in this condition. Workers exposed to BJV were assessed for venom allergy using questionnaires and immunological tests. The presence of BJV sensitization was determined through quantification of specific IgE. Allergens were studied using the Western blots and inhibition assays. Of the 67 workers evaluated, 7 (10.4%) presented specific IgE antibodies to BJV. Of those, 6 presented typical symptoms of an IgE-mediated allergic reaction when exposed to BJV. Venom sensitization was associated with length of employment (P=0.042), high levels of total IgE (P=0.034), atopy (P=0.051), and specific tasks, primarily the handling of...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jul 1, 1990·Annals of Emergency Medicine·D E Hogan, D J Dire
Dec 7, 1985·Lancet·J Schmutz, E Stahel
Nov 1, 1987·The Journal of Allergy and Clinical Immunology·A A Wadee, A R Rabson
Jan 1, 1983·Toxicon : Official Journal of the International Society on Toxinology·R D Theakston
Mar 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P KoppG Müllner
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A R ReimersU R Müller
Mar 1, 1959·The American Journal of the Medical Sciences·H M PARRISH, C B POLLARD
Aug 2, 1965·JAMA : the Journal of the American Medical Association·E F ELLIS, R T SMITH
Jul 2, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·F O S FrançaUNKNOWN Butantan Institute Antivenom Study Group
Jul 9, 2004·Current Opinion in Allergy and Clinical Immunology·Robert G Hamilton
Oct 12, 2004·Wilderness & Environmental Medicine·Daniel E Brooks, Kimberlie A Graeme
Jun 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ruth A Prescott, Paul C Potter
Jun 30, 2005·Current Opinion in Allergy and Clinical Immunology·Marek JutelCezmi A Akdis
Aug 12, 2005·American Journal of Industrial Medicine·Eva SuarthanaEvert Meijer
May 30, 2006·PLoS Medicine·José María GutiérrezDavid A Warrell

❮ Previous
Next ❯

Citations

May 13, 2014·Indian Heart Journal·Nicholas G Kounis, George D Soufras
Sep 28, 2015·The Journal of Allergy and Clinical Immunology·Philipp StarklStephen Joseph Galli
Jul 2, 2010·Wilderness & Environmental Medicine·William K Hayes, Stephen P Mackessy
Apr 12, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Leticia Gomes de PontesLucilene Delazari Dos Santos
Aug 10, 2012·QJM : Monthly Journal of the Association of Physicians·Geoffrey K IsbisterUNKNOWN ASP Investigators
Apr 28, 2009·Toxicon : Official Journal of the International Society on Toxinology·Scott A Weinstein, Daniel E Keyler
Apr 18, 2017·Experimental and Therapeutic Medicine·Haiwei YangShaoheng He
Jan 19, 2021·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Rodrigo Ligabue-Braun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
P KoppG Müllner
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A R ReimersU R Müller
The Journal of Allergy and Clinical Immunology
A A Wadee, A R Rabson
Toxicon : Official Journal of the International Society on Toxinology
Tamás MalinaZoltán Takács
© 2021 Meta ULC. All rights reserved