Predictors of cardiovascular events and associated mortality within two years of kidney transplantation

Transplantation Proceedings
P ChuangC R Parikh

Abstract

Cardiovascular disease is the most common cause of death after renal transplantation. Furthermore, acute coronary syndrome (ACS) attributable to coronary artery disease (CAD) accounts for the majority of deaths due to cardiovascular disease posttransplant. While renal transplantation is the treatment of choice for end-stage renal disease, understanding the causes of graft and patient loss is exceedingly important to improve outcomes. This observational case-controlled study included 780 patients who underwent a kidney transplant between 1989 and 2001 who experienced early ACS (within 2 years). Patients were compared with controls matched for gender, year of transplant, and age. The primary outcome was the occurrence of an ACS event within 2 years after renal transplantation. Cardiovascular disease was the most common cause of death, with all 13 cardiovascular deaths due to CAD. An additional 15 episodes of nonfatal ACS episodes occurred. Thirty-seven percent of early ACS occurred perioperatively, the majority in the first 3 posttransplant months. On multivariate analysis, diabetes (OR [odds ratio] 5.56; P = .0007), smoking (OR 3.56; P = .034), and prior transplant (OR 2.81; P = .047) were associated with early ACS. Diabetes, sm...Continue Reading

References

Oct 1, 1992·Transplantation·J D RussellD N Churchill
Aug 11, 1994·The New England Journal of Medicine·M Suthanthiran, T B Strom
Dec 22, 1994·The New England Journal of Medicine·P D King
Jul 1, 1996·Kidney International·A LaupacisN Muirhead
Aug 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S M ArendL A van Es
Jun 26, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E McGregorJ D Briggs
Apr 8, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S AakhusT E Widerøe
Apr 20, 2000·Journal of the American Society of Nephrology : JASN·Christian G RabbatDavid N Churchill
Aug 31, 2000·Journal of the American Society of Nephrology : JASN·Bertram L KasiskeJoseph Roel
Feb 22, 2001·Journal of the American Society of Nephrology : JASN·Akinlolu O OjoFriedrich K Port
Jun 8, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F GradausB E Strauer
Aug 18, 2001·American Journal of Nephrology·U KappesH Hohage
Jan 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claudio Ponticelli, Margarita Villa
Mar 26, 2002·Journal of the American Society of Nephrology : JASN·Claudio RigattoJohn Jeffery
Apr 18, 2002·Transplantation Proceedings·G Fernández-FresnedoM Arias
May 1, 2002·Transplantation·Gema Fernández-FresnedoManuel Arias
Oct 10, 2002·Kidney International·John S GillBrian J G Pereira
Dec 21, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Roberto S N KalilRobert S Gaston
Apr 30, 2003·Transplantation·Herwig-Ulf Meier-KriescheBruce Kaplan
Oct 29, 2003·Circulation·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jay Garg, George L Bakris

❮ Previous
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Citations

Sep 18, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·UNKNOWN European Renal Best Practice Transplantation Guideline Development Group
Apr 28, 2010·Journal of General Internal Medicine·Gaurav GuptaPeggy B Hasley
Jun 7, 2011·BMC Cardiovascular Disorders·Salvador Pita-FernándezAndres López-Muñiz
Sep 26, 2009·International Urology and Nephrology·Adam RemportIstvan Mucsi
Feb 16, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jeroen AaltenAndries J Hoitsma
Dec 17, 2009·Transplantation Proceedings·M CiapettiA Peris
Feb 10, 2009·Journal of Renal Care·Debbie SuttonKathryn Hart
Mar 19, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Miklos Z MolnarIstvan Mucsi
Jan 3, 2006·Transplantation Proceedings·A S LaurésJ Alvarez-Grande
Sep 14, 2011·Transplantation Proceedings·T AkagunM Sukru Sever
Jul 10, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Marie A ChisholmLaura L Mulloy
Aug 4, 2007·The International Journal of Artificial Organs·M Di Paolo, B Guidi
May 26, 2017·JAAPA : Official Journal of the American Academy of Physician Assistants·Shira Roth

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