Predictors of cerebral blood flow in patients with and without anemia

Journal of Applied Physiology
Matthew T BorzageJohn C Wood

Abstract

Sickle cell disease (SCD) is the most common cause of stroke in childhood and results primarily from a mismatch of cerebral oxygen supply and demand rather than arterial obstruction. However, resting cerebral blood flow (CBF) has not been examined in the general African American population, in whom obesity, hypertension, cerebrovascular disease, and diminished cerebrovascular reserve capacity are common. To better understand the underlying physiological substrate upon which SCD is superimposed, we measured CBF in 32 young (age 28 ± 10 yr), asymptomatic African American subjects with and without sickle cell trait (n= 14). To characterize the effects of chronic anemia, in isolation of sickle hemoglobin we also studied a cohort of 13 subjects with thalassemia major (n= 10), dyserythropoetic anemia (n= 1), or spherocytosis (n= 2). Blood was analyzed for complete blood count, hemoglobin electrophoresis, cell free hemoglobin, and lactate dehydrogenase. Multivariate regression analysis showed that oxygen content was the strongest predictor of CBF (r(2)= 0.33,P< 0.001). CBF declined rapidly in the second and third decades of life, but this drop was explained by reductions in cerebral gray matter. However, age effects persisted after co...Continue Reading

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Citations

Jun 7, 2016·American Journal of Hematology·Adam M BushJohn C Wood
Jan 27, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Meltem AkcaboyNecla Buyan
Dec 2, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Adam M BushJohn C Wood
Mar 1, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Julien Vincent BrugniauxPhilip N Ainslie
Jul 28, 2017·Brain Connectivity·Julie ColoignerJohn C Wood
Jan 22, 2019·Stroke; a Journal of Cerebral Circulation·Kristin P GuilliamsMichael M Dowling
Aug 8, 2020·The Journal of Physiology·James Duffin
Feb 25, 2017·Annals of Intensive Care·Hendrik J F HelmerhorstEvert de Jonge
Aug 9, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chau VuJohn C Wood
Jan 31, 2019·American Journal of Hematology·Yaqiong ChaiJohn C Wood
Nov 20, 2016·British Journal of Haematology·Michael M Dowling, Fenella J Kirkham
Mar 28, 2019·American Journal of Hematology·Jon A DetterichJohn C Wood
May 26, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Tshimanga M TatyNicole F O'Brien
Oct 14, 2020·Critical Care : the Official Journal of the Critical Care Forum·Josefine S BaekgaardUNKNOWN Traumabase® Study Group
Mar 9, 2021·Frontiers in Physiology·James DuffinJoseph A Fisher
Apr 24, 2021·American Journal of Hematology·Chau VuJohn C Wood
Nov 14, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Enfu TaoMizu Jiang

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