Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study.

Arthritis Care & Research
Daniel F McWilliamsDavid A Walsh

Abstract

To investigate possible predictors for lack of pain improvement after 1 year of treatment for early rheumatoid arthritis (RA). The Early Rheumatoid Arthritis Network (ERAN) database was used for analysis of baseline and 1-year pain data. The ERAN is a hospital-based inception cohort of 1,189 people. Short Form 36 questionnaire bodily pain scores were used to calculate change in pain at 1 year as the outcome. The proportion of the Disease Activity Score in 28 joints (DAS28) attributable to patient-reported components (joint tenderness and visual analog scale score; DAS28-P) at baseline was derived as a predictor. Predictors of less improvement in pain were investigated using adjusted odds ratios (OR(adj) ) generated by logistic regression, adjusting for 14 additional clinical and demographic covariates. Greater pain at baseline was associated with sex, high DAS28, worse mental health, and smoking. Most patients with early RA reported incomplete improvement in bodily pain after 1 year. The DAS28-P index did not significantly change in the patients whose disease remained active. Less improvement in pain was predicted by female sex (OR(adj) 3.41, 95% confidence interval [95% CI] 1.35-8.64) and a high DAS28-P index at baseline (OR(...Continue Reading

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Citations

Oct 31, 2012·Current Pain and Headache Reports·David A Walsh, Daniel F McWilliams
Dec 10, 2013·Best Practice & Research. Clinical Rheumatology·Suzanne M M Verstappen
Nov 19, 2013·Rheumatology·Daniel F McWilliamsDavid A Walsh
May 28, 2014·Nature Reviews. Rheumatology·David A Walsh, Daniel F McWilliams
Jan 3, 2013·Arthritis Care & Research·Patricia L DobkinGilles Boire
Nov 29, 2015·Annals of the Rheumatic Diseases·Gustaf WigerbladCamilla I Svensson
Aug 13, 2015·Best Practice & Research. Clinical Rheumatology·Fabiola AtzeniPiercarlo Sarzi-Puttini
Apr 22, 2016·Current Rheumatology Reports·Sean D BoydenYvonne C Lee
Apr 29, 2016·Rheumatology·Daniel F McWilliamsDavid A Walsh
Jan 20, 2016·Arthritis Care & Research·Reem AltawilJon Lampa
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Aug 8, 2018·Current Rheumatology Reviews·Fausto SalaffiPiercarlo Sarzi-Puttini
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Aug 2, 2018·Molecular Medicine Reports·Ling-Ling ZhouXue-Ping Zhou
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May 14, 2021·Pain Reports·Michael J LacagninaPeter M Grace
Nov 30, 2018·Neurochemistry International·Fernanda Regina HamannMaribel Antonello Rubin

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