Predictors of chronic kidney disease and utility of risk prediction scores in HIV-positive individuals

AIDS
Emily L WoolnoughJanine M Trevillyan

Abstract

The current study aimed to validate existing risk prediction scores and identify predictors of chronic kidney disease (CKD) in the setting of HIV. A retrospective cohort study of HIV-positive individuals (n = 748) with baseline estimated glomerular filtration rate (eGFR) more than 60 ml/min was conducted at the Alfred Hospital, Melbourne, Australia. Multivariable regression analysis was performed to determine factors associated with development of CKD, defined as two consecutive measurements of eGFR less than 60 ml/min. The performance of CKD risk scores proposed by the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group and Scherzer and colleagues were estimated by the area under the receiver operator curve (AUROC). CKD developed in 37 individuals (5.0%), at a median of 4.7 (interquartile range 2.2, 6.2) years. Older age [odds ratio (OR) 3.03, 95% confidence interval (CI): 1.20, 7.65, P = 0.02] and lower baseline eGFR (OR 10.39, 95% CI: 4.73, 22.83, P < 0.001) were associated with the development of CKD. Neither current, nor cumulative tenofovir disoproxil fumarate (TDF) use was associated with progression to CKD [current TDF hazard ratio (HR) 1.05, 95% CI: 0.54, 2.07, P = 0.88; cumulative TDF HR 1.03, 95% ...Continue Reading

References

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Citations

Jul 23, 2020·Revista latino-americana de enfermagem·Priscila Silva PontesRenata Karina Reis
Mar 18, 2020·AIDS Research and Therapy·Jack Edward HeronDavid M Gracey
Aug 3, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Win Min HanAnchalee Avihingsanon
Nov 3, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Win Min HanUNKNOWN IeDEA Asia-Pacific
Aug 31, 2021·Current Opinion in HIV and AIDS·Christine Hughes

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