Predictors of clinical pain intensity in patients with fibromyalgia syndrome

Current Rheumatology Reports
Roland Staud

Abstract

Central changes in pain processing have been previously reported in patients with fibromyalgia syndrome. These changes include decreased thresholds to mechanical and thermal stimuli (allodynia) and central sensitization, both of which are fundamental to the generation of clinical pain. Therefore, psychophysical measures of central pain processing may be useful predictors of clinical pain intensity of fibromyalgia syndrome patients. Previous studies of fibromyalgia syndrome patients have shown statistically significant correlations of psychophysical test results with clinical pain intensity. The tests used to characterize this important relationship were dependent on spinal cord pain mechanisms and included temporal summation of pain or wind-up and wind-up after-sensations. Particularly, the magnitude of wind-up after-sensations appeared to be one of the best predictors for clinical pain intensity of fibromyalgia syndrome patients (27%). Furthermore, the combination of tender point count, negative affect, and wind-up after-sensations accounted for approximately 50% of the variance in clinical pain intensity of fibromyalgia syndrome patients. Therefore, wind-up after-sensations, tender point count, and negative affect not only se...Continue Reading

References

Dec 1, 1992·Journal of Psychosomatic Research·M E GaskinM E Geisser
Dec 1, 1992·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·C S BurckhardtR M Bennett
Apr 11, 1992·The American Journal of Medicine·J I HudsonL Schlesinger
Sep 1, 1991·Pain·A H Dickenson, A F Sullivan
Oct 1, 1986·Journal of Consulting and Clinical Psychology·F J KeefeL H Muhlbaier
Feb 1, 1988·Arthritis and Rheumatism·R W SimmsJ H Mason
Mar 8, 1974·Brain Research·H E Torebjörk, R G Hallin
Sep 17, 1994·BMJ : British Medical Journal·P CroftA Silman
Jan 1, 1994·Scandinavian Journal of Rheumatology·C M Henriksson
Jul 1, 1996·Annals of the Rheumatic Diseases·P CroftA Silman
May 1, 1996·Rheumatic Diseases Clinics of North America·L J Crofford, M A Demitrack
Apr 1, 1996·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·J W JacobsJ W Bijlsma
Nov 19, 1997·Arthritis and Rheumatism·S R PillemerG P Chrousos
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·C J Woolf, M Costigan
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·A I Basbaum
Feb 25, 2000·Journal of Pain and Symptom Management·G J Bennett

❮ Previous
Next ❯

Citations

Jan 6, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Y J Zhu, T J Lu
Nov 28, 2006·Journal of Women's Health·Joan L F ShaverMary S Buntin
Feb 27, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·David A FishbainRennée S Rosomoff
May 2, 2015·Journal of Physical Therapy Science·Mustafa GülerÖzgür Taşpınar
Jan 3, 2012·The Journal of Pain : Official Journal of the American Pain Society·Carolina ValenciaSteven Z George
Jan 24, 2007·The European Journal of Neuroscience·Pascal FossatFrédéric Nagy
Nov 21, 2013·Pain Practice : the Official Journal of World Institute of Pain·Miriam W van IttersumJo Nijs
Aug 10, 2010·The Journal of Pain : Official Journal of the American Pain Society·Carolina ValenciaSteven Z George
Mar 13, 2019·European Heart Journal·Jonas TesarzAlexander K Schuster
Jul 30, 2011·AJNR. American Journal of Neuroradiology·P FeracoM Leonardi
Feb 18, 2012·European Journal of Pain : EJP·M BurgmerE Pogatzki-Zahn
Apr 9, 2020·European Journal of Pain : EJP·Wiebke GandhiPetra Schweinhardt
Jun 2, 2020·European Journal of Pain : EJP·Eleonora VecchioMarina de Tommaso
Feb 6, 2020·Arthritis & Rheumatology·Catherine S HubbardMarco L Loggia
Aug 7, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S E Kim, L Chang
Aug 4, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Stefano Delli PizziLaura Bonanni
Jan 1, 2015·Arthritis Research & Therapy·Dana L DaileyKathleen A Sluka
Apr 4, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Pablo de la CobaGustavo A Reyes Del Paso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.