Predictors of depression in youth with Crohn disease

Journal of Pediatric Gastroenterology and Nutrition
Jeffrey G ClarkEva M Szigethy

Abstract

The aim of the study was to determine whether infliximab use and other potential predictors are associated with decreased prevalence and severity of depression in pediatric patients with Crohn disease (CD). A total of 550 (n = 550) youth ages 9 to 17 years with biopsy-confirmed CD were consecutively recruited as part of a multicenter randomized controlled trial. Out of the 550, 499 patients met study criteria and were included in the analysis. At recruitment, each subject and a parent completed the Children's Depression Inventory (CDI). A child or parent CDI score ≥  12 was used to denote clinically significant depressive symptoms (CSDS). Child and parent CDI scores were summed to form total CDI (CDIT). Infliximab use, demographic information, steroid use, laboratory values, and Pediatric Crohn's Disease Activity Index (PCDAI) were collected as the potential predictors of depression. Univariate regression models were constructed to determine the relations among predictors, CSDS, and CDIT. Stepwise multivariate regression models were constructed to predict the relation between infliximab use and depression while controlling for other predictors of depression. Infliximab use was not associated with a decreased proportion of CSDS ...Continue Reading

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Citations

Aug 8, 2015·Journal of Clinical Pharmacy and Therapeutics·C S MartinS Fica
Mar 9, 2017·Acta Neuropsychiatrica·Áine Abautret-DalyAndrew Harkin
Jan 5, 2014·Journal of Pediatric Gastroenterology and Nutrition·Aoife O'Donovan
Jul 11, 2014·Current Opinion in Pediatrics·Divya KeethyEva Szigethy
Feb 11, 2014·Journal of Pediatric Gastroenterology and Nutrition·Guadalupe Salazar
Jun 12, 2019·International Journal of Behavioral Medicine·Luuk StapersmaElisabeth M W J Utens
Mar 15, 2019·Current Gastroenterology Reports·Hannibal Person, Laurie Keefer
Nov 30, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Aravind ThavamaniReema Gulati
Mar 30, 2017·International Journal of Psychiatry in Clinical Practice·Áine Abautret-DalyAndrew Harkin
Oct 30, 2020·Journal of Pediatric Psychology·Marissa N BaudinoJohn M Chaney
Aug 3, 2020·Journal of Pediatric Gastroenterology and Nutrition·Anne GourdonneauRaphaël Enaud
Jun 10, 2017·Deutsches Ärzteblatt International·Jan DäbritzMichael Radke
Feb 11, 2021·International Journal of Molecular Sciences·Davide BanfiAndreina Baj
Jan 15, 2021·Journal of Affective Disorders·Elettra MancusoFrancesco Andreozzi

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